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- Title
The Structural and Molecular Mechanisms of Mycobacterium tuberculosis Translational Elongation Factor Proteins.
- Authors
Fang, Ning; Wu, Lingyun; Duan, Shuyan; Li, Jixi
- Abstract
Targeting translation factor proteins holds promise for developing innovative anti-tuberculosis drugs. During protein translation, many factors cause ribosomes to stall at messenger RNA (mRNA). To maintain protein homeostasis, bacteria have evolved various ribosome rescue mechanisms, including the predominant trans-translation process, to release stalled ribosomes and remove aberrant mRNAs. The rescue systems require the participation of translation elongation factor proteins (EFs) and are essential for bacterial physiology and reproduction. However, they disappear during eukaryotic evolution, which makes the essential proteins and translation elongation factors promising antimicrobial drug targets. Here, we review the structural and molecular mechanisms of the translation elongation factors EF-Tu, EF-Ts, and EF-G, which play essential roles in the normal translation and ribosome rescue mechanisms of Mycobacterium tuberculosis (Mtb). We also briefly describe the structure-based, computer-assisted study of anti-tuberculosis drugs.
- Subjects
ELONGATION factors (Biochemistry); RIBOSOMES; MYCOBACTERIUM tuberculosis; ANTITUBERCULAR agents; BACTERIAL physiology; MESSENGER RNA; DRUG target
- Publication
Molecules, 2024, Vol 29, Issue 9, p2058
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29092058