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- Title
Barriers to systemic application of virus-based vectors in gene therapy: lessons from adenovirus type 5.
- Authors
Jönsson, Franziska; Kreppel, Florian
- Abstract
Currently, virus-based vectors, namely derivatives of the adenovirus, are frequently used in a wide variety of ex vivo or local gene therapeutic applications. However, the efficacy of virus-based vectors in systemic applications is presently still extremely limited. Complex interactions of the various vector types with the patient's organism hinder successful vector deployment. Exemplary, here we summarize barriers to systemic application of Adenovirus-based vectors leading either to acute toxic effects or rapid vector neutralization and discuss strategies to overcome these barriers aiming to develop more efficient vector types.
- Subjects
ADENOVIRUSES; VIRAL genetics; GENETIC vectors; GENE therapy; THERAPEUTICS
- Publication
Virus Genes, 2017, Vol 53, Issue 5, p692
- ISSN
0920-8569
- Publication type
Article
- DOI
10.1007/s11262-017-1498-z