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- Title
Straightforward trifluoroacylation of oxazoles – scalable, cost-effective way toward diverse 2-(trifluoroacetyl)oxazoles.
- Authors
Savchenko, Vladyslav S.; Geraschenko, Oleksandr V.; Khodakivskyi, Pavlo V.; Druzhenko, Tetiana V.; Moskvina, Viktoria S.; Ryabukhin, Sergey V.; Volochnyuk, Dmitriy M.
- Abstract
Feasible, scalable, and cost-effective method for the synthesis of low-molecular 2-(trifluoroacetyl)oxazoles from the corresponding oxazoles and trifluoroacetic anhydride was elaborated. The procedure was scaled up to 70 g of the desired ketones in a single run. Tolerance of the oxazole core to various functional group transformations was demonstrated. Thus, synthesis of various building blocks approved the possibility of using 2-(trifluoroacetyl)oxazoles as a starting materials for medicinal chemistry.
- Subjects
OXAZOLES; TRANSFORMATION groups; PHARMACEUTICAL chemistry; FUNCTIONAL groups; NITROALDOL reactions
- Publication
Chemistry of Heterocyclic Compounds, 2023, Vol 59, Issue 6/7, p472
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-023-03218-7