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- Title
1,3-Dipolar cycloaddition of diphenylnitrilimine and 5-arylmethylidene-1-phenyl-1,5,6,7-tetrahydro-4H-indazol-4-ones to afford novel spiro[indazole-5,3′-pyrazole] derivatives.
- Authors
Ren, Demin; Kuang, Guoqiang; Li, Xiaofang
- Abstract
Novel 4'-aryl-1,2',5'-triphenyl-2',4',6,7-tetrahydrospiro[indazole-5,3'-pyrazol]-4(1H)-ones have been synthesized in moderate yields by 1,3-dipolar cycloaddition of 5-arylmethylidene-1-phenyl-1,5,6,7-tetrahydro-4H-indazol-4-ones and diphenylnitrilimine, generated in situ from N-phenylbenzohydrazonoyl chloride and triethylamine. According to structural analyses by NMR spectroscopy and single crystal X-ray diffraction method, the reaction proceeds regioselectively affording products with C(5)-C(3') connectivity at the spiro center.
- Subjects
RING formation (Chemistry); NITRILIMINES; METHYLIDENES; CHEMICAL derivatives; ORGANIC synthesis
- Publication
Chemistry of Heterocyclic Compounds, 2018, Vol 54, Issue 12, p1117
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-019-02401-z