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- Title
Expression of miRNA-451 and miRNA-885 in Meningiomas.
- Authors
BARAN, OZGUR; KARAOGLU, ADİL CAN; KARA, ERDOGAN; BUDUN, ORHAN; KATAR, SALIM; YILMAZ, SEDA GULEÇ; AKDENIZ, FATMA TUBA; AMBARCIOGLU, MEHMET AKİF; DEMIREL, NAİL; TURK, OKAN; OZDEMIR, NURIYE GÜZİN; YALTIRIK, CUMHUR KAAN; ISBIR, TURGAY
- Abstract
Background/Aim: Meningiomas are one of the most common intracranial tumors, accounting for 30% of the tumors of the central nervous system. MicroRNAs (miRNAs) are noncoding RNAs containing approximately 18-22 nucleotides that regulate gene expression by interfering with transcription or inhibiting translation. Recent studies have reported that miRNAs could provide information about the molecular pathogenesis of several types of tumors. This study aimed to examine the expression levels of miRNA-885 and -451 and to determine their potential roles as biomarkers in meningioma. Materials and Methods: In total, 29 patients with meningioma (9 males and 20 females) were included in this study. The expression levels of miRNA were determined using real-time polymerase chain reaction. In addition, receiver operating characteristic curve analysis was used to analyze the predictive potential of miRNAs. Results: Our results indicated a significant increase in miRNA-451 expression levels (p=0.003); however, there was no significant change in miRNA-885 expression levels (p=0.139) in patients with meningioma compared with the control group. Moreover, miRNA-885 and miRNA-451 expression levels did not differ significantly based on the histopathological grade of meningioma. Conclusion: miRNA-451 may be a novel potential marker for the diagnosis and prognosis, and a target for meningioma treatment.
- Subjects
MICRORNA; MENINGIOMA; BRAIN tumor genetics; BRAIN tumor treatment; POLYMERASE chain reaction
- Publication
In Vivo, 2023, Vol 37, Issue 6, p2473
- ISSN
0258-851X
- Publication type
Article
- DOI
10.21873/invivo.13354