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- Title
The Number of Comorbidities Predicts Renal Outcomes in Patients with Stage 3–5 Chronic Kidney Disease.
- Authors
Lee, Wen-Chin; Lee, Yueh-Ting; Li, Lung-Chih; Ng, Hwee-Yeong; Kuo, Wei-Hung; Lin, Pei-Ting; Liao, Ying-Chun; Chiou, Terry Ting-Yu; Lee, Chien-Te
- Abstract
Background: Chronic kidney disease (CKD) is a global health threat affecting approximately 10% of the adult population worldwide. Multimorbidity is common in CKD, but its impacts on disease outcomes are seldom investigated. Methods: This prospective cohort analysis followed patients, who were part of a multidisciplinary CKD care program, for 10 years. We aimed to determine the impact of multimorbidity on renal outcomes. Results: Overall, 1463 patients with stage 3–5 CKD were enrolled and stratified by the number of comorbidities. Mean follow-up time was 6.39 ± 1.19 years. We found that stage 3–5 CKD patients with at least three comorbidities at enrollment initiated dialysis earlier (hazard ratio (HR): 2.971) than patients without comorbidities. Risk factors for multimorbidity included old age, smoking, and proteinuria. Conclusions: By analyzing the number of comorbidities, a simple and readily applicable method, we demonstrated an association between multimorbidity and poor renal outcomes in stage 3–5 CKD patients. In addition to current guideline-based approaches, our results suggest an urgent need for tailored CKD care strategies for high-risk groups.
- Subjects
KIDNEY diseases; NEPHROLOGISTS; CHRONIC diseases; COHORT analysis
- Publication
Journal of Clinical Medicine, 2018, Vol 7, Issue 12, p493
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm7120493