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- Title
Around LTD Hypothesis in Motor Learning.
- Authors
Hirano, Tomoo
- Abstract
Long-term depression (LTD) at parallel fiber-Purkinje neuron synapses has been regarded as a primary cellular mechanism for motor learning. However, this hypothesis has been challenged. Demonstration of normal motor learning under LTD-suppressed conditions suggested that motor learning can occur without LTD. Synaptic plasticity mechanisms other than LTD have been found at various synapses in the cerebellum. Animals may achieve motor learning using several types of synaptic plasticity in the cerebellum including LTD.
- Subjects
LONG-term synaptic depression; MOTOR learning; VESTIBULO-ocular reflex; PURKINJE cells; NEUROPLASTICITY; CEREBELLUM development
- Publication
Cerebellum, 2014, Vol 13, Issue 5, p645
- ISSN
1473-4222
- Publication type
Article
- DOI
10.1007/s12311-014-0581-4