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- Title
Suppressive effects of dRYamides on feeding behavior of the blowfly, Phormia regina.
- Authors
Toru Maeda; Yuki Nakamura; Hajime Shiotani; Hojo, Masaru K.; Taishi Yoshii; Takanori Ida; Takahiro Sato; Morikatsu Yoshida; Mikiya Miyazato; Masayasu Kojima; Mamiko Ozaki
- Abstract
Recently, dRYamides-1 and -2 have been identified as ligands of the neuropeptide Y-like receptor CG5811 in Drosophila melanogaster. It has also been reported in brief that injection of dRYamide-1suppresses the early feeding behavior called proboscis extension reflex (PER) in the blowfly Phormia regina. Immunohistochemical analyses by our group using anti-dRYamide-1 antiserum indicated symmetrical localization of 32 immunoreactive cells in the brain of P. regina. In order to analyze the mechanism of feeding regulation, we further investigated the effects of dRYamide-1 and -2 on intake volume, PER exhibition, and activity of the sugar receptor neuron. After injection of dRYamide-1 or -2, flies showed little change in the intake volume of sucrose solution, but a significant depression of PER to sucrose. Injection of dRYamide-1 revealed a significant decrease in the responsiveness of the sugar receptor neuron, although the injection of dRYamide-2 did not. These results suggest that the dRYamide peptides decrease feeding motivation in flies, as evaluated by PER threshold, through a mechanism that partially involves desensitization of the sugar receptor neuron.
- Subjects
PEPTIDE analysis; BIOACTIVE compounds; BLOWFLIES; INSECT feeding &; feeds; LIGANDS (Biochemistry); SUGAR receptors; ANIMAL behavior
- Publication
Zoological Letters, 2016, Vol 2, p1
- ISSN
2056-306X
- Publication type
Article
- DOI
10.1186/s40851-015-0034-z