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- Title
The effects of EGb761 on lipopolysaccharideinduced depressive-like behaviour in C57BL/6J mice.
- Authors
YUEHAN ZHAO; YONGDONG ZHANG; FANG PAN
- Abstract
There is an increasing body of evidence for the involvement of inflammation and brain-derived neurotrophic factor (BDNF) in depression. Ginkgo extract EGb76' possesses anti-inflammatory, antioxidative, anti-arteriosclerosis, and neuroprotective activities. But the effect of EGb76' on lipopolysaccharide (LPS)-induced depressive-like behaviours has not been investigated. The present study mainly aimed to examine the antidepressant-like activities of Ginkgo extract EGb76' in mice after lipopolysaccharide administration. C57BL/6J male mice were pretreated with EGb76' or vehicle for '0 days. Then, a single dose of lipopolysaccharide was intraperitoneally administrated to mice to induce depressive-like behaviour. Forced swim test (FST), tail suspension test (TST), and sucrose preference test were performed to evaluate the depressive-like behaviours of the mice. Locomotor activity was examined by open field test. Levels of brain-derived neurotrophic factor, TNF-a, IL-'ß, IL-6, IL-'7A, and IL-'0 in hippocampus tissue homogenate were measured using ELISA kits. We found that LPS administration induced significant depressive-like behaviours, higher levels of tumour necrosis factor a (TNF-a), interleukin (IL) 'ß, IL-6, and IL-'7A, but lower levels of BDNF and IL-'0 in hippocampus tissue homogenate of the mice from the vehicle group compared to the control mice. Pretreatment with middle dose ('00 mg/kg/day) and high dose ('50 mg/kg/day) of EGb76' significantly attenuated depressive-like behaviours without affecting spontaneous locomotor activity, and inhibited the changes of hippocampal cytokines and BDNF induced by LPS administration. We conclude that EGb76' has antidepressant-like activities in mice with LPS-induced depressive-like behaviours.
- Subjects
PHYSIOLOGICAL effects of lipopolysaccharides; NEUROTROPHINS; MENTAL depression genetics; GINKGO -- Health aspects; NEUROPROTECTIVE agents
- Publication
Central European Journal of Immunology, 2015, Vol 40, Issue 1, p11
- ISSN
1426-3912
- Publication type
Article
- DOI
10.5114/ceji.2015.49427