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- Title
Persistence of Anti-SE36 Antibodies Induced by the Malaria Vaccine Candidate BK-SE36/CpG in 5–10-Year-Old Burkinabe Children Naturally Exposed to Malaria.
- Authors
Nebie, Issa; Palacpac, Nirianne Marie Q.; Bougouma, Edith Christiane; Diarra, Amidou; Ouédraogo, Alphonse; D'Alessio, Flavia; Houard, Sophie; Tiono, Alfred B.; Cousens, Simon; Horii, Toshihiro; Sirima, Sodiomon B.
- Abstract
Information on the dynamics and decline/persistence of antibody titres is important in vaccine development. A recent vaccine trial in malaria-exposed, healthy African adults and children living in a malaria hyperendemic and seasonal area (Ouagadougou, Burkina Faso) was the first study in which BK-SE36/CpG was administered to different age groups. In 5- to 10-year-old children, the risk of malaria infection was markedly lower in the BK-SE36/CpG arm compared to the control arm. We report here data on antibody titres measured in this age-group after the high malaria transmission season of 2021 (three years after the first vaccine dose was administered). At Year 3, 83% of children had detectable anti-SE36 total IgG antibodies. Geometric mean antibody titres and the proportion of children with detectable anti-SE36 antibodies were markedly higher in the BK-SE36/CpG arm than the control (rabies) arm. The information obtained in this study will guide investigators on future vaccine/booster schedules for this promising blood-stage malaria vaccine candidate.
- Subjects
MALARIA vaccines; ANTIBODY titer; IMMUNOGLOBULINS; VACCINE trials; MALARIA
- Publication
Vaccines, 2024, Vol 12, Issue 2, p166
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines12020166