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- Title
Brief structural insight into the allosteric gating mechanism of BK (Slo1) channel1.
- Authors
Almássy, János; Nánási, Péter P.
- Abstract
The big conductance Ca2+-dependent K+ channel, also known as BK, MaxiK, Slo1, or KCa1.1, is a ligand- and voltage-gated K+ channel. Although structure-function studies of the past decades, involving mutagenesis and electrophysiological measurements, revealed fine details of the mechanism of BK channel gating, the exact molecular details remained unknown until the quaternary structure of the protein has been solved at a resolution of 3.5 Å using cryo-electron microscopy. In this short review, we are going to summarize these results and interpret the gating model of the BK channel in the light of the recent structural results.
- Subjects
MUTAGENESIS; ELECTROPHYSIOLOGY; QUATERNARY structure; CRYOELECTRONICS; PROTEIN structure
- Publication
Canadian Journal of Physiology & Pharmacology, 2019, Vol 97, Issue 6, p498
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2018-0516