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- Title
Obesity, asthma prevalence and IL-4: Roles of inflammatory cytokines, adiponectin and neuropeptide Y.
- Authors
Lu, Yanxia; Van Bever, Hugo P. S.; Lim, Tow Keang; Kuan, Win Sen; Goh, Daniel Yam Thiam; Mahadevan, Malcolm; Sim, Tiong Beng; Ho, Roger; Larbi, Anis; Ng, Tze Pin
- Abstract
Background Obesity is associated with asthma risk and severity, but the underlying biological mechanisms are poorly understood. We hypothesized that cytokine markers of systemic inflammation, and adiponectin and neuropeptide Y ( NPY) markers of immuno-modulating and neurohormonal regulation are involved in the obesity-asthma association. Methods We explored the relationships between body mass index ( BMI), C-reactive protein ( CRP), IL-6, TNF-α, adiponectin and NPY with asthma prevalence and IL-4 levels in 70 youth with asthma and 69 age- and gender-matched healthy controls using cross-sectional and longitudinal data. Results Mean BMI level was higher among patients with asthma than healthy controls (p < 0.001). In logistic regression models controlling for potential confounders, independent associations with asthma prevalence were found for obesity (p = 0.001), increasing tertiles of CRP (linear trend p < 0.001), IL-6 (linear trend p < 0.001) and lowest and highest tertiles of TNF-α (quadratic trend p < 0.05), increasing adiponectin (linear p = 0.022) and decreasing tertiles of NPY (linear trend p = 0.001). Among patients with asthma, NPY level was positively correlated with adiponectin (p < 0.05) and TNF-α (p < 0.05), and levels of NPY and IL-6 were significantly associated with IL-4 level at baseline and 1-year follow-up. Conclusions The obesity-asthma association was not explained by systemic inflammation. Specifically, CRP, TNF-a, IL-6, NPY and adiponectin were independently associated with asthma prevalence. NPY and IL-6 were associated with IL-4 marker of allergic airway inflammation in asthma and should be further investigated as prognostic markers of asthma outcomes.
- Subjects
ASTHMA risk factors; OBESITY; INTERLEUKIN-4; PHYSIOLOGICAL effects of cytokines; ADIPONECTIN; NEUROPEPTIDE Y
- Publication
Pediatric Allergy & Immunology, 2015, Vol 26, Issue 6, p530
- ISSN
0905-6157
- Publication type
Article
- DOI
10.1111/pai.12428