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- Title
High prevalence of food sensitisation in young children with liver disease: a clue to food allergy pathogenesis?
- Authors
Brown, Chrysothemis; Haringman, Natasha; Davies, Charlotte; Gore, Claudia; Hussain, Munther; Mieli-Vergani, Giorgina; Vergani, Diego; Warner, John O.; Marks, Stephen D.; Boyle, Robert J.
- Abstract
Background The pathogenesis of food allergy is not completely understood - animal models suggest hepatic mechanisms may be important for immune tolerance to orally ingested antigens, but there is little direct evidence for this in humans. Objectives We investigated whether there is an association between liver dysfunction or transplantation in young children and Ig E sensitisation to food. Methods We evaluated paired pre- and post- liver transplant sera from children aged 0-36 months treated at a single centre during 2001-2008. Sera were assayed for total Ig E and cow's milk, egg and peanut-specific Ig E. We quantified hepatic dysfunction pre-transplant using the Paediatric End-stage Liver Disease ( PELD) score. We also assessed 70 children after renal transplant to establish whether any association between liver transplant and food sensitisation was organ specific. Results Paired sera were available from 50 of 94 children who had a liver transplant during the study period. 35 of 50 (70%) had Ig E sensitisation (≥0.35 kUa/l) to ≥1 food pre-transplant and 18 (36%) post-transplant (p = 0.001). Ten (20%) children had food-specific Ig E levels that carry high probability of challenge-confirmed food allergy pre-transplant. Food sensitisation pre-transplant was associated with severity of liver dysfunction [mean (s.d.) pre-transplant PELD score 1.52 (0.13) in food sensitised, 0.77 (0.22) in non-sensitised children p = 0.004]. Total Ig E level was raised in 34/42 (81%) pre-transplant and fell significantly post-transplant. Interview assessment of the parents of 40 children revealed that 13 (33%) had a history consistent with food allergy. These findings were not replicated in the renal transplant group. Conclusions Young children with severe liver dysfunction appear to have a high prevalence of food sensitisation. Hepatic mechanisms may therefore be important for establishing immune tolerance to dietary antigens in humans.
- Subjects
ALLERGIES; FOOD allergy; LIVER diseases; BLOOD plasma; IMMUNITY; IMMUNOGLOBULINS
- Publication
Pediatric Allergy & Immunology, 2012, Vol 23, Issue 8, p771
- ISSN
0905-6157
- Publication type
Article
- DOI
10.1111/pai.12011