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- Title
Apolipoprotein E Highly Correlates with AβPP- and Tau-Related Markers in Human Cerebrospinal Fluid.
- Authors
Vuletic, Simona; Li, Ge; Peskind, Elaine R.; Kennedy, Hal; Marcovina, Santica M.; Leverenz, James B.; Petrie, Eric C.; Lee, Virginia M-Y.; Galasko, Douglas; Schellenberg, Gerard D.; Albers, John J.
- Abstract
We assessed cerebrospinal fluid (CSF) levels of apolipoprotein E (apoE), phospholipid transfer protein (PLTP) activity, cholesterol, secreted amyloid-β protein precursor α and β (sAβPPα, sAβPPβ), amyloid-β peptides 1–40 (Aβ_{40}) and 1–42 (Aβ_{42}), total tau and tau phosphorylated at threonine 181 (pTau) in neurologically healthy, cognitively intact adults. ApoE significantly correlated with sAβPPα (r = 0.679), sAβPPβ (r = 0.634), Aβ_{40} (r = 0.609), total and pTau (r = 0.589 and r = 0.673, respectively, all p < 0.001), PLTP activity (r = 0.242, p = 0.002) and cholesterol (r = 0.194, p < 0.01). PLTP activity significantly correlated with sAβPPα (r = 0.292), sAβPPβ (r = 0.281), total and pTau (r = 0.265 and 0.258, respectively; all p &les; 0.001). Using partial correlations of CSF biomarkers with apoE, PLTP activity, age and gender, apoE remained significantly correlated with sAβPPα, sAβPPβ, Aβ_{40}, total and pTau (p < 0.001). The presence of apoE ℇ2 was associated with lower levels of apoE, PLTP activity and Aβ_{42}, while APOEℇ4} had no significant impact on any of the measured variables. Our data suggest that there is a significant physiological link between apoE and AβPP, as well as between apoE and tau in neurologically healthy, cognitively intact individuals.
- Subjects
APOLIPOPROTEIN E; CEREBROSPINAL fluid; PHOSPHOLIPIDS; AMYLOID beta-protein; AMYLOID beta-protein precursor
- Publication
Journal of Alzheimer's Disease, 2008, Vol 15, Issue 3, p409
- ISSN
1387-2877
- Publication type
Article
- DOI
10.3233/JAD-2008-15307