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- Title
SARS-CoV-2 RNA in exhaled air of hospitalized COVID-19 patients.
- Authors
Kurver, Lisa; van den Kieboom, Corné H.; Lanke, Kjerstin; Diavatopoulos, Dimitri A.; Overheul, Gijs J.; Netea, Mihai G.; ten Oever, Jaap; van Crevel, Reinout; Mulders-Manders, Karin; van de Veerdonk, Frank L.; Wertheim, Heiman; Schouten, Jeroen; Rahamat-Langendoen, Janette; van Rij, Ronald P.; Bousema, Teun; van Laarhoven, Arjan; de Jonge, Marien I.
- Abstract
Knowledge about contagiousness is key to accurate management of hospitalized COVID-19 patients. Epidemiological studies suggest that in addition to transmission through droplets, aerogenic SARS-CoV-2 transmission contributes to the spread of infection. However, the presence of virus in exhaled air has not yet been sufficiently demonstrated. In pandemic situations low tech disposable and user-friendly bedside devices are required, while commercially available samplers are unsuitable for application in patients with respiratory distress. We included 49 hospitalized COVID-19 patients and used a disposable modular breath sampler to measure SARS-CoV-2 RNA load in exhaled air samples and compared these to SARS-CoV-2 RNA load of combined nasopharyngeal throat swabs and saliva. Exhaled air sampling using the modular breath sampler has proven feasible in a clinical COVID-19 setting and demonstrated viral detection in 25% of the patients.
- Subjects
COVID-19; SARS-CoV-2; HOSPITAL patients; AIR sampling; RNA; MICROBIOLOGICAL aerosols
- Publication
Scientific Reports, 2022, Vol 12, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-022-13008-4