We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
EGFR-Tyrosine Kinase Inhibitor Retreatment in Non-Small-Cell Lung Cancer Patients Previously Exposed to EGFR-TKI: A Systematic Review and Meta-Analysis.
- Authors
Michelon, Isabella; Vilbert, Maysa; do Rego Castro, Caio Ernesto; Stecca, Carlos; Dacoregio, Maria Inez; Rizzo, Manglio; Cláudio Cordeiro de Lima, Vladmir; Cavalcante, Ludimila
- Abstract
We performed a systematic review and meta-analysis to assess the efficacy of EGFR-tyrosine kinase inhibitors (TKI) retreatment in advanced/metastatic non-small-cell lung cancer (NSCLC) patients. We systematically searched PubMed, Embase, Cochrane databases, ASCO, and ESMO websites for studies evaluating EGFR-TKI retreatment in advanced/metastatic NSCLC patients. All analyses were performed using R software (v.4.2.2). We included 19 studies (9 CTs and 10 retrospective cohorts) with a total of 886 patients. In a pooled analysis of all patients during retreatment with TKI, median OS was 11.7 months (95% confidence interval [CI] 10.2–13.4 months) and PFS was 3.2 months (95% CI 2.5–3.9 months). ORR was 15% (95% CI 10–21%) and DCR was 61% (95% CI 53–67%). The subanalysis by generation of TKI in the rechallenge period revealed a slightly better ORR for patients on 3rd generation TKI (p = 0.05). Some limitations include the high heterogeneity of some of the analyses and inability to perform certain subanalyses. Our results unequivocally support the benefit of EGFR-TKI rechallenge in EGFR-mutated NSCLC patients progressing on TKI treatment after a TKI-free interval. These findings may be especially valuable in areas where access to novel therapeutic drugs and clinical trials is limited.
- Subjects
PROTEIN-tyrosine kinases; EPIDERMAL growth factor receptors; NON-small-cell lung carcinoma; PROTEIN-tyrosine kinase inhibitors; PROTEIN receptors
- Publication
Journal of Personalized Medicine, 2024, Vol 14, Issue 7, p752
- ISSN
2075-4426
- Publication type
Article
- DOI
10.3390/jpm14070752