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- Title
PD-L1, CD4+, and CD8+ Tumor-Infiltrating Lymphocytes (TILs) Expression Profiles in Melanoma Tumor Microenvironment Cells.
- Authors
Caraban, Bogdan Marian; Matei, Elena; Cozaru, Georgeta Camelia; Aşchie, Mariana; Deacu, Mariana; Enciu, Manuela; Bălţătescu, Gabriela Izabela; Chisoi, Anca; Dobrin, Nicolae; Petcu, Lucian; Gheorghe, Emma; Hangan, Laurențiu-Tony; Roșu, Mihai Cătălin; Orasanu, Cristian Ionuț; Nicolau, Antonela-Anca
- Abstract
(1) Background: Because melanoma is an aggressive tumor with an unfavorable prognosis, we aimed to characterize the PD-L1 expression in melanomas in association with T cell infiltrates because PD-1/PD-L1 blockade represents the target in treating melanoma strategy. (2) Methods: The immunohistochemical manual quantitative methods of PD-L1, CD4, and CD8 TILs were performed in melanoma tumor microenvironment cells. (3) Results: Most of the PD-L1 positive, expressing tumors, have a moderate score of CD4+ TILs and CD8+TILs (5−50% of tumor area) in tumoral melanoma environment cells. The PD-L1 expression in TILs was correlated with different degrees of lymphocytic infiltration described by the Clark system (X2 = 8.383, p = 0.020). PD-L1 expression was observed often in melanoma cases, with more than 2−4 mm of Breslow tumor thickness being the associated parameters (X2 = 9.933, p = 0.014). (4) Conclusions: PD-L1 expression represents a predictive biomarker with very good accuracy for discriminating the presence or absence of malign tumoral melanoma cells. PD-L1 expression was an independent predictor of good prognosis in patients with melanomas.
- Subjects
PROGRAMMED cell death 1 receptors; PROGRAMMED death-ligand 1; TUMOR-infiltrating immune cells; TUMOR microenvironment; CD8 antigen; CD4 antigen
- Publication
Journal of Personalized Medicine, 2023, Vol 13, Issue 2, p221
- ISSN
2075-4426
- Publication type
Article
- DOI
10.3390/jpm13020221