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- Title
SOX11 is useful in differentiating cyclin D1 -positive diffuse large B-cell lymphoma from mantle cell lymphoma.
- Authors
Shih-Chuan Hsiao; Ribera Cortada, Inmaculada; Colomo, Luis; Hongtao Ye; Hongxiang Liu; Szu-Yin Kuo; Shu-Hui Lin; Sheng-Tsung Chang; Kuo, Ted U.; Campo, Elias; Shih-Sung Chuang
- Abstract
Aims: To characterize the frequency and clinicopathological features of cyclin D1-positive diffuse large B-cell lymphoma (DLBCL) and the usefulness of SOX11 in the differential diagnosis from mantle cell lymphoma (MCL). Methods and results: We retrospectively stained 206 consecutive DLBCLs for cyclin D1, and identified three (1.5%) positive cases, comprising two in the elderly with necrosis, and a third with a starry-sky pattern. All three cases shared the same non-germinal centre B-cell (non-GCB) phenotype [CD5-/CD10-/bcl-6 + /MUM1 + /SOX11-], Epstein-Barr virus (EBV) negativity, and absence of CCND1 aberrations by fluorescence in-situ hybridization. The third case showed both BCL6 and MYC rearrangements: a double-hit lymphoma. In the same period there were 22 MCLs, all expressing cyclin D1, with 89% cases expressing SOX11, a frequency that is statistically different from cyclin D1-positive DLBCL. Notably, we identified a pleomorphic MCL initially misdiagnosed as DLBCL. A separate cohort of 98 DLBCL cases was negative for SOX11, with only one case expressing cyclin D1 with a GCB phenotype (CD10+/bcl-6+/MUM1-). The two patients with tumour necrosis rapidly died of disease. The other two were in complete remission after immunochemotherapy, Conclusions: Cyclin D1-positive DLBCLs are rare, and they are negative for SOX11 or CCND1 aberration. SOX11 is useful in differentiating cyclin D1-positive DLBCL from MCL.
- Subjects
CYCLINS; GROWTH factors; B cells; LYMPHOMAS; RETICULOENDOTHELIAL granulomas; TUMORS
- Publication
Histopathology, 2012, Vol 61, Issue 4, p685
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/j.1365-2559.2012.04260.x