We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants.
- Authors
Moser, Brittany A.; Escalante-Buendia, Yoseline; Steinhardt, Rachel C.; Rosenberger, Matthew G.; Cassaidy, Britteny J.; Naorem, Nihesh; Chon, Alfred C.; Nguyen, Minh H.; Tran, Ngoctran T.; Esser-Kahn, Aaron P.
- Abstract
Adjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-α and IL-6. Here we present small molecule NF-κB inhibitors that can be used in combination with an immune adjuvant to both decrease markers associated with poor tolerability and improve the protective response of vaccination. Additionally, we synthesize a library of honokiol derivatives identifying several promising candidates for use in vaccine formulations.
- Subjects
SMALL molecules; VACCINES; BACTERIAL vaccines; IMMUNE response
- Publication
Frontiers in Immunology, 2020, Vol 11, pN.PAG
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2020.511513