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- Title
A pharmacokinetic and residual study of sulfadiazine/trimethoprim in mandarin fish ( Siniperca chuatsi) with single- and multiple-dose oral administrations.
- Authors
Wang, W.; Luo, L.; Xiao, H.; Zhang, R.; Deng, Y.; Tan, A.; Jiang, L.
- Abstract
A pharmacokinetic and tissue residue study of sulfadiazine combined with trimethoprim ( SDZ/ TMP = 5/1) was conducted in Siniperca chuatsi after single- (120 mg/kg) or multiple-dose (an initial dose of 120 mg/kg followed by a 5-day consecutive dose of 60 mg/kg) oral administrations at 28 °C. The absorption half-life ( t1/2 α), elimination half-life ( t1/2 β), volume of distribution (Vd/F), and the total body clearance (ClB/F) for SDZ and TMP were 4.3 ± 1.7 to 6.3 ± 1.8 h and 2.4 ± 1.0 to 3.9 ± 0.9 h, 25.9 ± 4.5 to 53.0 ± 5.6 h and 11.8 ± 3.5 to 17.1 ± 3.4 h, 2.34 ± 0.78 to 3.67 ± 0.99 L/kg and 0.39 ± 0.01 to 1.33 ± 0.57 L/kg, and 0.03 ± 0.01 to 0.06 ± 0.01 L/kg·h and 0.02 ± 0.01 to 0.05 ± 0.01 L/kg·h, respectively, after the single dose. The elimination half-life ( t1/2 β) and mean residue time ( MRT) for SDZ and TMP were 68.8 ± 7.8 to 139.8 ± 12.3 h and 34.0 ± 5.5 to 56.1 ± 6.8 h, and 99.3 ± 6.1 to 201.7 ± 11.5 h and 49.1 ± 3.5 to 81.0 ± 5.1 h, respectively, after the multiple-dose administration. The daily oral SDZ/ TMP administration might cause a high tissue concentration and long t1/2 β, thereby affecting antibacterial activity. The withdrawal time for this oral SDZ/ TMP formulation (according to the accepted guidelines in Europe for maximum residue limits, <0.1 mg/kg of tissues for sulfonamides, and <0.05 mg/kg for TMP) should not be <36 days for fish.
- Subjects
FISH as laboratory animals; PHARMACOKINETICS; SULFADIAZINE; TRIMETHOPRIM; DRUG metabolism; HALF-life (Biology)
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 2016, Vol 39, Issue 3, p309
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1111/jvp.12279