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- Title
Tissue c--myc protein expression and immune response in systemic lupus erythematosus.
- Authors
Husby, G.; Williams Jr., R. C.; Watt, Rosemary A.; West, S. G.; Tung, K. S. K.
- Abstract
Frozen sections of kidney tissue from 12 patients with systemic lupus erythematosus were examined for the expression of oncogene proteins. Polyclonal rabbit antibody to c-myc peptide or to whole 65,000 D c-myc protein, was used to identify c-myc protein within tissue sections. Patterns of nuclear staining in the Hep-2 cell line were similar to those seen with monospecific human SLE sera showing anti-Sm reactivity. In addition c-myc staining was not abolished by prior incubation of tissue sections with human serum containing anti-Sm antibodies. Five of 12 kidney biopsy tissues from patients with systemic lupus erythematosus (SLE) showed positive speckled c-myc protein staining within nuclei of monocyte/macrophage cells of glomerular tufts. Positive staining was in all instances completely abolished by prior absorption of anti-c-myc antibody with c-myc protein. No c-myc protein was identified within SLE immune complex deposits.
- Subjects
SYSTEMIC lupus erythematosus; TISSUES; KIDNEYS; LABORATORY rabbits; IMMUNE response; PROTEINS
- Publication
Clinical & Experimental Immunology, 1987, Vol 69, Issue 3, p493
- ISSN
0009-9104
- Publication type
Article