We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Distinct mechanisms determine organ left-right asymmetry patterning in an uncoupled way.
- Authors
Huang, Sizhou; Xu, Wenming; Su, Bingyin; Luo, Lingfei
- Abstract
Disruption of Nodal in the lateral plate mesoderm (LPM) usually leads to left-right (LR) patterning defects in multiple organs. However, whether the LR patterning of organs is always regulated in a coupled way has largely not yet been elucidated. In addition, whether other crucial regulators exist in the LPM that coordinate with Nodal in regulating organ LR patterning is also undetermined. In this paper, after briefly summarizing the common process of LR patterning, the most puzzling question regarding the initiation of asymmetry is considered and the divergent mechanisms underlying the uncoupled LR patterning in different organs are discussed. On the basis of cases in which different organ LR patterning is determined in an uncoupled way via an independent mechanism or at a different time, we propose that there are other critical factors in the LPM that coordinate with Nodal to regulate heart LR asymmetry patterning during early LR patterning. Also watch the .
- Subjects
DEVELOPMENTAL biology; REPRODUCTIVE health; ORGANS (Anatomy); HISTOPATHOLOGY; NODES of Ranvier; DIVERGENT thinking
- Publication
BioEssays, 2014, Vol 36, Issue 3, p293
- ISSN
0265-9247
- Publication type
Article
- DOI
10.1002/bies.201300128