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- Title
Is melatonin associated with pro-inflammatory cytokine activity and liver fibrosis in non-alcoholic fatty liver disease (NAFLD) patients?
- Authors
Sohrabi, Masoudreza; Gholami, Ali; Amirkalali, Bahareh; Taherizadeh, Mahsa; Kolahdoz, Mahsa; SafarnezhadTameshkel, Fahimeh; Aghili, Sheida; Hajibaba, Marzieh; Zamani, Farhad; Toosi, Mohsen Nasiri; Keyvani, Hossein
- Abstract
Aim: The associations between serum levels of melatonin and concentrations of tumor necrosis factor (TNF)-a and interleukin (IL)-6 were assessed among patients with different degrees of non-alcoholic fatty liver disease. Background: Non-alcoholic fatty liver disease (NAFLD) has become a very common worldwide disease. Methods: In this cross-sectional study, adult patients diagnosed with fatty liver disease by Fibroscan evaluation were included if they met the inclusion/exclusion criteria for NAFLD. The participants were categorized into the three following groups: 1) fibrosis> 9.1KP and steatosis >290 dbm; 2) fibrosis: 6-9.0 KP and steatosis 240-285; and 3) fibrosis < 5.8 KP and steatosis<240 dbm. Post-fasting, 5 ml of venous blood was collected for laboratory assessment, and a questionnaire including demographic, anthropometric, laboratories and clinical data was completed. Results: A total of 97 participants were included. The mean age was 42.21±11 years, and 59 patients (60.0%) were female. Melatonin levels as well as pro-inflammatory cytokines levels were correlated with advancing fibrosis and steatosis in univariate analysis. A significant association was observed between these cytokines and advancing fibrosis, severe steatosis levels, and melatonin concentrations. Furthermore, in the multiple linear regression model, melatonin levels showed a significant association with these cytokines. Conclusion: Melatonin may have protective effects on tissue injury during advancing liver fibrosis via cytokines modulation. Therefore, it can be considered as a potential therapeutic management strategy for NAFLD.
- Subjects
CYTOKINES; INTERLEUKINS; STATISTICS; LIVER; FATTY liver; ANTHROPOMETRY; CROSS-sectional method; FIBROSIS; MELATONIN; TUMOR necrosis factors; QUESTIONNAIRES; DESCRIPTIVE statistics
- Publication
Gastroenterology & Hepatology from Bed to Bench, 2021, Vol 14, Issue 3, p229
- ISSN
2008-2258
- Publication type
Article