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- Title
Targeting the Host Mitochondria as a Novel Human Cytomegalovirus Antiviral Strategy.
- Authors
Bachman, Lauryn O.; Zwezdaryk, Kevin J.
- Abstract
Human cytomegalovirus (HCMV) exploits host mitochondrial function to promote viral replication. HCMV gene products have been described to directly interact and alter functional or structural aspects of host mitochondria. Current antivirals against HCMV, such as ganciclovir and letermovir, are designed against viral targets. Concerns with the current antivirals include toxicity and viral resistance. Targeting host mitochondrial function is a promising alternative or complimentary antiviral approach as (1) drugs targeting host mitochondrial function interact with host targets, minimizing viral resistance, and (2) host mitochondrial metabolism plays key roles in HCMV replication. This review describes how HCMV alters mitochondrial function and highlights pharmacological targets that can be exploited for novel antiviral development.
- Subjects
HUMAN cytomegalovirus; VIRAL replication; ANTIVIRAL agents; GANCICLOVIR; MITOCHONDRIA
- Publication
Viruses (1999-4915), 2023, Vol 15, Issue 5, p1083
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v15051083