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- Title
Antibody Titer Correlates with Omicron Infection in Vaccinated Healthcare Workers.
- Authors
Mollura, Maximiliano; Sarti, Riccardo; Levi, Riccardo; Pozzi, Chiara; Azzolini, Elena; Politi, Letterio S.; Mantovani, Alberto; Barbieri, Riccardo; Rescigno, Maria
- Abstract
The advent of vaccines against SARS-CoV-2 has drastically reduced the level of hospitalization with severe COVID-19 disease in infected individuals. However, the diffusion of variants of concern still challenge the protection conferred by vaccines raised against the wild-type form of the virus. Here, we have characterized the antibody response to the BNT162b2 (Comirnaty) mRNA vaccine in patients infected with the Omicron variant. We analyzed a population of 4354 vaccinated healthcare workers (HCW) from 7 different hospitals in Italy and monitored infection with SARS-CoV-2 Omicron. We correlated infection with the antibody response after vaccination. We found that a lower level of IgG, younger age, and the presence of allergies correlate with increased infection during the Omicron wave, and that infections correlate with wild-type spike protein antibody titers below 350 BAU/mL. These results support the necessity of a fourth booster dose, particularly for individuals with lower levels of antibodies.
- Subjects
ITALY; MEDICAL personnel; SARS-CoV-2 Omicron variant; ANTIBODY titer; IMMUNOGLOBULINS; COVID-19; BOOSTER vaccines
- Publication
Viruses (1999-4915), 2022, Vol 14, Issue 12, p2605
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v14122605