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- Title
Rounding up the usual suspects in O<sub>2</sub> sensing: CO, NO, and H<sub>2</sub>S!
- Authors
Fandrey, Joachim
- Abstract
Oxygen sensing by the carotid body is essential in vertebrates to adapt to reduced arterial oxygen tension. In this issue of Science Signaling, Yuan et al. report an intricate signaling system to transduce a physical parameter--oxygen tension--into a biological cellular signal (neural discharge) through changes in the production of carbon monoxide (CO), the second messenger cyclic guanosine monophosphate, and hydrogen sulfide (H2S).
- Subjects
OXYGEN detectors; HUMAN cellular signal transduction; CARBON monoxide; GUANYLIC acid; HYDROGEN sulfide; CAROTID body
- Publication
Science Signaling, 2015, Vol 8, Issue 373, p1
- ISSN
1945-0877
- Publication type
Article
- DOI
10.1126/scisignal.aab1665