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- Title
Increased MCL-1 expression predicts poor prognosis and disease recurrence in acute myeloid leukemia.
- Authors
Li, Xi-xi; Zhou, Jing-dong; Wen, Xiang-mei; Zhang, Ting-juan; Wu, De-hong; Deng, Zhao-qun; Zhang, Zhi-hui; Lian, Xin-yue; He, Pin-fang; Yao, Xin-yu; Lin, Jiang; Qian, Jun
- Abstract
Background: Altered expression of the BCL-2 family member MCL-1 has been linked to the progression and outcome of various malignancies. Recently, MCL-1 inhibitor S63845 was reported to kill MCL-1-dependent cancer cells and has potential value in clinical application. Purpose: Herein, we reported MCL-1 expression pattern in Chinese de novo acute myeloid leukemia (AML) and its impact on prognosis and may provide theoretical basis for AML patients using MCL-1 inhibitor in clinics. Real-time quantitative PCR was carried out to detect the transcript of MCL-1 in AML patients. Results: MCL-1 expression was significantly up-regulated in AML compared with controls (P=0.042). We divided the patients into two groups (higher and lower expression of MCL-1) based on the median level. Among both non-acute promyelocytic leukemia (APL) and cytogenetically normal AML (CN-AML), patients with higher expression of MCL-1 correlated with lower complete remission (CR) rate (P=0.031 and 0.004, respectively) and shorter overall survival (OS) time (P=0.008 and 0.004, respectively) compared with those with lower expression of MCL-1. Meanwhile, Cox regression analyses revealed that overexpression of MCL-1 acted as an independent risk factor for OS in non-APL patients and CN-AML patients (P=0.011 and 0.045, respectively). In follow-up patients, MCL-1 expression level decreased after CR compared with newly diagnosis time (P=0.020) and increased after relapse (P=0.004). Conclusion: Our findings suggest that higher expression of MCL-1 predicts poor prognosis and can be used for disease monitoring.
- Subjects
ACUTE myeloid leukemia; PROGNOSIS; DISEASE relapse; ACUTE diseases; REGRESSION analysis
- Publication
OncoTargets & Therapy, 2019, Vol 12, p3295
- ISSN
1178-6930
- Publication type
Article
- DOI
10.2147/OTT.S194549