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- Title
Evolution of SIVmac239 following serial passaging in humanized mice.
- Authors
Curlin, James Z.; Schmitt, Kimberly; Remling‐Mulder, Leila; Morrison, Jared; Baczenas, John J.; Tibbits, Corina Valencia; Goff, Kelly; O'Connor, Shelby; Stenglein, Mark; Marx, Preston; Akkina, Ramesh
- Abstract
Serial passage of SIVmac239 allows for greater understanding of the genetic changes necessary for cross‐species transmission of primate lentiviruses into humans. Using humanized mice, we show that adaptive mutations continue to accumulate in SIVmac239 during four serial passages, with persistent CD4+ T cell decline and increases in plasma viral loads.
- Subjects
MICE; VIRAL load; T cells; LENTIVIRUSES; CD4 antigen; RHESUS monkeys
- Publication
Journal of Medical Primatology, 2022, Vol 51, Issue 5, p284
- ISSN
0047-2565
- Publication type
Article
- DOI
10.1111/jmp.12614