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- Title
Effect of viral status on recurrence after liver resection for patients with hepatitis B virus-related hepatocellular carcinoma.
- Authors
Kubo, Shoji; Hirohashi, Kazuhiro; Tanaka, Hiromu; Tsukamoto, Tadashi; Shuto, Taichi; Yamamoto, Takatsugu; Ikebe, Takashi; Wakasa, Kenichi; Nishiguchi, Shuhei; Kinoshita, Hiroaki; Kubo, S; Hirohashi, K; Tanaka, H; Tsukamoto, T; Shuto, T; Yamamoto, T; Ikebe, T; Wakasa, K; Nishiguchi, S; Kinoshita, H
- Abstract
<bold>Background: </bold>Risk factors for recurrence after resection of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) require more precise definition.<bold>Methods: </bold>Forty patients who underwent liver resection for HBV-related HCC were studied. Their clinical findings, laboratory data (including viral status), pathologic findings, and operative methods were evaluated for recurrence risk in univariate and multivariate analyses.<bold>Results: </bold>The HB envelope (HBe) antigen, wild-type HBV, intrahepatic metastases, elevated serum activities of aspartate aminotransferase and alanine aminotransferase, and moderately or severely active hepatitis were more likely to be found in patients with a high viral load than in patients with a low viral load. Precore mutant-type HBV was more likely to be found in patients with a low viral load than in patients with a high viral load. The platelet count was significantly lower in the patients with a high viral load. A high viral load, the presence of wild-type HBV, the absence of anti-HBe, the absence of precore mutant-type HBV, Child score B, a low platelet count, and a positive surgical margin were risk factors for recurrence in univariate analysis. A nonanatomic resection tended to be a risk factor. A high viral load and positive surgical margin were independent risk factors for recurrence.<bold>Conclusions: </bold>The measurement of viral load and detection of anti-HBe, wild-type HBV, and precore mutant-type HBV are useful for estimating a patient's prognosis after resection of HBV-related HCC.
- Publication
Cancer (0008543X), 2000, Vol 88, Issue 5, p1016
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/(SICI)1097-0142(20000301)88:5<1016::AID-CNCR10>3.0.CO;2-V