We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of Single Monthly Instillations of Intra-Vesical Bacillus Calmette-Guerin Maintenance Therapy with Southwest Oncology Group Regimen in Non-Muscle Invasive Bladder Cancer Patients-A Retrospective Analysis In a Single Institute.
- Authors
lashay, Alireza; Taleghani, Saeed; Masoumi, Navid
- Abstract
<bold>Purpose: </bold>To compare the efficacy and complication rate of monthly instillations of Bacillus Calmette-Guerin (BCG) as maintenance therapy in intermediate and high risk Non-Muscle Invasive Bladder Cancer (NMIBC) patients with the current standard Southwest Oncology Group (SWOG) protocol.<bold>Materials and Methods: </bold>In this observational retrospective study, 40 intermediate and high risk NMIBC patients, receiving standard BCG maintenance regimen, were compared with another 40 NMIBC patients, undergoing monthly intra-vesical instillations of BCG with regard to recurrence, progression and major and minor adverse effects.<bold>Results: </bold>The two groups were similar in their basic characteristics except for the older age in the monthly instillation group ( 70.95 ± 9.66 years vs. 64 ± 8.8, p = 0.001). Study objectives between the monthly instillation group and the standard group, including recurrence ( 17.5 % vs. 25%, p = 0.34) and progression rate ( 7.5% vs. 10%, p = 0.54) did not show statistically significant difference. Major and minor complication rate also did not show any difference between the two groups.<bold>Conclusion: </bold>In addition to the currently recommended standard protocol of BCG maintenance therapy, our study shows that the monthly regimen can be recommended in intermediate and high risk NMIBC patients without compromising the efficacy of the treatment.
- Subjects
INTRAVESICAL administration; CANCER invasiveness; BLADDER cancer; RETROSPECTIVE studies; ONCOLOGY; TREATMENT effectiveness; CANCER relapse; IMMUNOMODULATORS; NON-muscle invasive bladder cancer; BCG vaccines
- Publication
Urology Journal, 2022, Vol 19, Issue 2, p106
- ISSN
1735-1308
- Publication type
journal article
- DOI
10.22037/uj.v18i.6491