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- Title
Effect of Malva Neglecta Wallr on Ethylene Glycol Induced Kidney Stones.
- Authors
Saremi, Jamileh; Kargar-Jahroomi, Hossein; Poorahmadi, Mohammad
- Abstract
<bold>Purpose: </bold>The aim of this study was to investigate the anti-urolithiasis effects of aqueous extracts of Malva neglecta Wallr on ethylene glycol and ammonium chloride induced kidney stones in a rat model.<bold>Materials and Methods: </bold>A total number of 64 male Wistar rats were randomly divided into eight groups equally: group I (normal control), group II (disease control), groups III and IV (sham), groups V and VI (preventive groups), and groups VII and VIII (curative groups). Group I received tap drinking water, groups III and IV were given intra-peritoneal injections of 200 and 800 mg/kg aqueous extracts for 28 days. Groups II, V, VI, VII, and VIII received 1% ethylene glycol plus 0.25% ammonium chloride in drinking water for 28 days. Groups V and VI were given intra- peritoneal injections of 200 and 800 mg/kg aqueous extracts for 28 days and groups VII and VIII received intra-peritoneal injections of 200 and 800 mg/kg aqueous extracts from the 14th day of the experiment. After 28 days the kidneys were removed and observed for calcium oxalate (CaOx) deposits and tubulointerstitial changes.<bold>Results: </bold>The extract significantly decreased CaOx deposits and tubulointerstitial damage in the preventive groups (P < .001). In curative groups, a low dosage of extract, reduced kidney oxalate deposits and tubulointerstitial damage (P < .05). In addition a significant decrease was observed in crystal deposition and tubulointerstitial damage in high dosed group (P < .001). However, high dosed preventive and curative groups seemed to be more effective (P ≤ .001).<bold>Conclusion: </bold>Malva neglecta Wallr has beneficial effects on preventing and treating CaOx deposition and decreasing tubulointerstitial damage on a dosage dependent manner. These effects may be due to the components presented in this plant such as saponins, flavonoids, mucilage, and phenolic compounds.
- Subjects
KIDNEY stones; ETHYLENE glycol; MALVA; CALCIUM oxalate; KIDNEY tubules; LABORATORY rats; URINARY calculi; EXTRACTS; ANIMAL experimentation; PLANTS; RATS; PLANT extracts; ETHYLENE glycols; AMMONIUM chloride; ACYCLIC acids; THERAPEUTICS
- Publication
Urology Journal, 2015, Vol 12, Issue 6, p2387
- ISSN
1735-1308
- Publication type
journal article