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Maximum Tolerated Dose Evaluation of the AMPA Modulator Org 26576 in Healthy Volunteers and Depressed Patients.
Published in:
Drugs in R&D, 2012, v. 12, n. 3, p. 127, doi. 10.2165/11634360-000000000-00000
By:
- Nations, Kari;
- Bursi, Roberta;
- Dogterom, Peter;
- Ereshefsky, Larry;
- Gertsik, Lev;
- Mant, Tim;
- Schipper, Jacques
Publication type:
Article
Antidepressant Drug-Drug Interaction Profile Update.
Published in:
Drugs in R&D, 2005, v. 6, n. 6, p. 323, doi. 10.2165/00126839-200506060-00002
By:
- Ereshefsky, Larry;
- Jhee, Stanford;
- Grothe, Dale
Publication type:
Article
Pharmacokinetic Profile and Clinical Efficacy of Long-Acting Risperidone: Potential Benefits of Combining an Atypical Antipsychotic and a New Delivery System.
Published in:
Drugs in R&D, 2005, v. 6, n. 3, p. 129, doi. 10.2165/00126839-200506030-00001
By:
- Ereshefsky, Larry;
- Mannaert, Erik
Publication type:
Article
THE PLACEBO CONUNDRUM: MITIGATING THE RESPONSE AT THE SITE LEVEL.
Published in:
Schizophrenia Bulletin, 2020, v. 46, p. S45, doi. 10.1093/schbul/sbaa031.101
By:
- Hassman, Howard;
- Cohen, Elan;
- Walling, David;
- Wyka, Katarzyna;
- Grindell, Vera;
- Glass, Steven;
- Ball, Roberta;
- Styczynski, John;
- Lobb, Jaclyn;
- Hazzard, Dakota;
- Joseph, Ashok;
- Ereshefsky, Larry
Publication type:
Article
What Is Causing the Reduced Drug-Placebo Difference in Recent Schizophrenia Clinical Trials and What Can be Done About It?
Published in:
Schizophrenia Bulletin, 2010, v. 36, n. 3, p. 504, doi. 10.1093/schbul/sbn110
By:
- Kemp, Aaron S.;
- Schooler, Nina R.;
- Kalali, Amir H.;
- Alphs, Larry;
- Anand, Ravi;
- Awad, George;
- Davidson, Michael;
- Dubé, Sanjay;
- Ereshefsky, Larry;
- Gharabawi, Georges;
- Leon, Andrew C.;
- Lepine, Jean-Pierre;
- Potkin, Steven G.;
- Vermeulen, An
Publication type:
Article
The Use of Individually Tailored Environmental Supports to Improve Medication Adherence and Outcomes in Schizophrenia.
Published in:
Schizophrenia Bulletin, 2008, v. 34, n. 3, p. 483
By:
- Velligan, Dawn I.;
- Diamond, Pamela M.;
- Mintz, Jim;
- Maples, Natalie;
- Li, Xueying;
- Zeber, John;
- Ereshefsky, Larry;
- Lam, Yui-Wing F.;
- Castillo, Desiree;
- Miller, Alexander L.
Publication type:
Article
Defining and Assessing Adherence to Oral Antipsychotics: A Review of the Literature.
Published in:
Schizophrenia Bulletin, 2006, v. 32, n. 4, p. 724
By:
- Velligan, Dawn I.;
- Lam, Yui-Wing Francis;
- Glahn, David C.;
- Barrett, Jennifer A.;
- Maples, Natalie J.;
- Ereshefsky, Larry;
- Miller, Alexander L.
Publication type:
Article
Mapping of validated apathy scales onto the apathy diagnostic criteria for neurocognitive disorders.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079997
By:
- Bawa, Kritleen Kaur;
- Sankhe, Krushnaa;
- Md, Daniel Bateman;
- Cummings, Jeffrey L.;
- Ereshefsky, Larry;
- Husain, Masud;
- Ismail, Zahinoor;
- Manera, Valeria;
- Mintzer, Jacobo;
- Moebius, Hans J.;
- Mortby, Moyra E;
- Porsteinsson, Anton P.;
- Robert, Philippe;
- Miller, David S.;
- Lanctôt, Krista L.
Publication type:
Article
Quantitative EEG as a translational measure for the assessment of ATH‐1017 neurophysiological changes in mild‐to‐moderate Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.056531
By:
- Hua, Xue;
- Church, Kevin;
- Walker, William;
- L'Hostis, Philippe;
- Ereshefsky, Larry;
- Kawas, Leen;
- Moebius, Hans J.
Publication type:
Article
Diagnostic criteria for apathy in neurocognitive disorders.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 12, p. 1892, doi. 10.1002/alz.12358
By:
- Miller, David S.;
- Robert, Philippe;
- Ereshefsky, Larry;
- Adler, Lawrence;
- Bateman, Daniel;
- Cummings, Jeff;
- DeKosky, Steven T.;
- Fischer, Corinne E.;
- Husain, Masud;
- Ismail, Zahinoor;
- Jaeger, Judith;
- Lerner, Alan J.;
- Li, Abby;
- Lyketsos, Constantine G.;
- Manera, Valeria;
- Mintzer, Jacobo;
- Moebius, Hans J.;
- Mortby, Moyra;
- Meulien, Didier;
- Pollentier, Stephane
Publication type:
Article
Review of the pharmacokinetics, pharmacogenetics, and drug interaction potential of antidepressants: Focus on venlafaxine.
Published in:
Depression & Anxiety (1091-4269), 2000, v. 12, p. 30, doi. 10.1002/1520-6394(2000)12:1+<30::AID-DA4>3.0.CO;2-G
By:
- Ereshefsky, Larry;
- Dugan, Daniel
Publication type:
Article
PHARMACOKINETICS, PHARMACODYNAMICS, SAFETY, AND TOLERABILITY OF LY3202626, A NOVEL BACE1 INHIBITOR, IN HEALTHY SUBJECTS AND PATIENTS WITH ALZHEIMER’S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P418, doi. 10.1016/j.jalz.2016.06.791
By:
- Willis, Brian A.;
- Lowe, Stephen L.;
- Daugherty, Leslie L.;
- Dean, Robert A.;
- English, Brett;
- Ereshefsky, Larry;
- Gevorkyan, Hakop;
- James, Douglas E.;
- Jhee, Stanford;
- Lin, Qun;
- Lo, Albert;
- Mergott, Dustin J.;
- Monk, Scott A.;
- Nakano, Masako;
- Zimmer, Jennifer A.;
- Irizarry, Michael C.
Publication type:
Article
The novel BACE inhibitor MK-8931 dramatically lowers cerebrospinal fluid Aβ peptides in healthy subjects following single- and multiple-dose administration
Published in:
2012
By:
- Forman, Mark;
- Palcza, John;
- Tseng, Jack;
- Leempoels, Jos;
- Ramael, Steven;
- Han, David;
- Jhee, Stanford;
- Ereshefsky, Larry;
- Tanen, Michael;
- Laterza, Omar;
- Dockendorf, Marissa;
- Krishna, Gopal;
- Ma, Lei;
- Wagner, John;
- Troyer, Matthew
Publication type:
Abstract
BACE inhibitor LY2886721 safety and central and peripheral PK and PD in healthy subjects (HSs)
Published in:
2012
By:
- Martenyi, Ferenc;
- Dean, Robert A.;
- Lowe, Stephen;
- Nakano, Masako;
- Monk, Scott;
- Willis, Brian A.;
- Gonzales, Celedon;
- Mergott, Dustin;
- Leslie, Daugherty;
- May, Patrick;
- James, Audia;
- Gevorkyan, Hakop;
- Jhee, Stanford;
- Ereshefsky, Larry;
- Citron, Martin
Publication type:
Abstract
Safety and pharmacokinetics of the novel BACE inhibitor MK-8931 in healthy subjects following single- and Multiple-Dose administration
Published in:
2012
By:
- Tseng, Jack;
- Dockendorf, Marissa;
- Krishna, Gopal;
- Ma, Lei;
- Palcza, John;
- Leempoels, Jos;
- Ramael, Steven;
- Han, David;
- Jhee, Stanford;
- Ereshefsky, Larry;
- Wagner, John;
- Troyer, Matthew;
- Forman, Mark
Publication type:
Abstract
Diurnal and intersubject variability of cerebrospinal fluid biomarkers, Aβ-40/42, alpha-synuclein and DJ-1 in healthy volunteers
Published in:
2012
By:
- Ereshefsky, Larry;
- Frasier, Mark;
- Yen, Mark;
- Jhee, Stanford;
- Marek, Kenneth;
- Taylor, Peggy;
- Sherman, Molly;
- Caspell, Chelsea;
- Coffey, Chris;
- Schlossmacher, Michael;
- Sherer, Todd
Publication type:
Abstract
Effect of human cerebrospinal fluid sampling frequency on amyloid-β levels
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2012, v. 8, n. 4, p. 295, doi. 10.1016/j.jalz.2011.05.900
By:
- Li, Jinhe;
- Llano, Daniel A.;
- Ellis, Teresa;
- LeBlond, David;
- Bhathena, Anahita;
- Jhee, Stanford S.;
- Ereshefsky, Larry;
- Lenz, Robert;
- Waring, Jeffrey F.
Publication type:
Article
The role for CSF dynabridging studies in developing new therapies for Alzheimer's disease
Published in:
2009
By:
- Ereshefsky, Larry;
- Jhee, Stanford S.;
- Yen, Mark;
- Moran, Samira V.
Publication type:
Abstract
Oral amyloid anti-aggregating agent ELND005 is measurable in CSF and brain of healthy adult men
Published in:
2009
By:
- Garzone, Pamela;
- Koller, Martin;
- Pastrak, Aleksandra;
- Jhee, Stanford S.;
- Ereshefsky, Larry;
- Moran, Samira;
- Cedarbaum, Jesse M.;
- Xu, Victor;
- Ross, Brian
Publication type:
Abstract
Aβ variability and effect of gamma secretase inhibition on cerebrospinal fluid levels of Aβ in healthy volunteers
Published in:
2009
By:
- Soares, Holly;
- Raha, Nancy;
- Sikpi, Matthew;
- Liston, Dane;
- Brodney, Mike;
- Coffman, Karen;
- Tate, Barbara;
- Qiu, Ruolun;
- Wang, Ellen Q.;
- Li, Xiaoxi;
- Hidi, Rabia;
- Banerjee, Subhashis;
- Jhee, Stanford;
- Ereshefsky, Larry;
- Fullerton, Terence
Publication type:
Abstract
P4-366: GSI-953, a potent and selective gamma-secretase inhibitor: Modulation of beta-amyloid peptides and plasma and cerebrospinal fluid pharmacokinetic/pharmacodynamic relationships in humans
Published in:
2008
By:
- Frick, Glen;
- Raje, Sangeeta;
- Wan, Hong;
- Forlow, Stephen B.;
- Balliet, Carrie;
- Pastore, Alicia;
- Burczynski, Michael E.;
- Jhee, Stan;
- Ereshefsky, Larry;
- Paul, Jeffrey
Publication type:
Abstract
O4-03-02: The gamma secretase inhibitor MK-0752 acutely and significantly reduces CSF Abeta40 concentrations in humans
Published in:
2006
By:
- Rosen, Laura B.;
- Stone, Julie A.;
- Plump, Andrew;
- Yuan, Jinyu;
- Harrison, Tim;
- Flynn, Mary;
- Dallob, Aimee;
- Matthews, Catherine;
- Stevenson, Donna;
- Schmidt, Dennis;
- Palmieri, Theresa;
- Leibowitz, Mark;
- Jhee, Stanford;
- Ereshefsky, Larry;
- Salomon, Ronald;
- Winchell, Greg;
- Shearman, Mark S.;
- Murphy, M. Gail;
- Gottesdiener, Keith M.
Publication type:
Abstract
O4-03-02: The gamma secretase inhibitor MK-0752 acutely and significantly reduces CSF Abeta40 concentrations in humans
Published in:
2006
By:
- Rosen, Laura B.;
- Stone, Julie A.;
- Plump, Andrew;
- Yuan, Jinyu;
- Harrison, Tim;
- Flynn, Mary;
- Dallob, Aimee;
- Matthews, Catherine;
- Stevenson, Donna;
- Schmidt, Dennis;
- Palmieri, Theresa;
- Leibowitz, Mark;
- Jhee, Stanford;
- Ereshefsky, Larry;
- Salomon, Ronald;
- Winchell, Greg;
- Shearman, Mark S.;
- Murphy, M. Gail;
- Gottesdiener, Keith M.
Publication type:
Abstract
Intraindividual Variability of the Dextromethorphan/Dextrorphan (DM/DP) Ratio in Extensive Metabolizers.
Published in:
Clinical Pharmacology & Therapeutics, 1996, v. 59, n. 2, p. 137, doi. 10.1038/sj.clpt.1996.46
By:
- Riesenman, Cara L.;
- Francis Lam, Y.W.;
- Ereshefsky, Larry
Publication type:
Article
Clinical Consult.
Published in:
Brown University Psychopharmacology Update, 1999, v. 10, n. 1, p. 4
By:
- Ereshefsky, Larry
Publication type:
Article
Clinical consult.
Published in:
Brown University Psychopharmacology Update, 1998, v. 9, n. 3, p. 3
By:
- Ereshefsky, Larry
Publication type:
Article
The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients.
Published in:
Science Translational Medicine, 2016, v. 8, n. 363, p. 1, doi. 10.1126/scitranslmed.aad9704
By:
- Kennedy, Matthew E.;
- Stamford, Andrew W.;
- Xia Chen;
- Cox, Kathleen;
- Cumming, Jared N.;
- Dockendorf, Marissa F.;
- Egan, Michael;
- Ereshefsky, Larry;
- Hodgson, Robert A.;
- Hyde, Lynn A.;
- Jhee, Stanford;
- Kleijn, Huub J.;
- Kuvelkar, Reshma;
- Wei Li;
- Mattson, Britta A.;
- Hong Mei;
- Palcza, John;
- Scott, Jack D.;
- Tanen, Michael;
- Troyer, Matthew D.
Publication type:
Article
Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson's disease.
Published in:
2017
By:
- Eidson, Lori;
- Kannarkat, George;
- Barnum, Christopher;
- Chang, Jianjun;
- Chung, Jaegwon;
- Caspell-Garcia, Chelsea;
- Taylor, Peggy;
- Mollenhauer, Brit;
- Schlossmacher, Michael;
- Ereshefsky, Larry;
- Yen, Mark;
- Kopil, Catherine;
- Frasier, Mark;
- Marek, Kenneth;
- Hertzberg, Vicki;
- Tansey, Malú;
- Eidson, Lori N;
- Kannarkat, George T;
- Barnum, Christopher J;
- Schlossmacher, Michael G
Publication type:
journal article
Pharmacokinetic and Pharmacodynamic Interactions of Oral Midazolam with Ketoconazole, Fluoxetine, Fluvoxamine, and Nefazodone.
Published in:
Journal of Clinical Pharmacology, 2003, v. 43, n. 11, p. 1274, doi. 10.1177/0091270003259216
By:
- Lam, Y. W. Francis;
- Alfaro, Cara L.;
- Ereshefsky, Larry;
- Miller, Michael
Publication type:
Article
Effect of Venlafaxine versus Fluoxetine on Metabolism of Dextromethorphan, a CYP2D6 Probe.
Published in:
Journal of Clinical Pharmacology, 2001, v. 41, n. 4, p. 443, doi. 10.1177/009127000104100411
By:
- Amchin, Jess;
- Ereshefsky, Larry;
- Zarycranski, William;
- Taylor, Karen;
- Albano, Dominick;
- Klockowski, Patricia M.
Publication type:
Article
CYP2D6 Inhibition by Fluoxetine, Paroxetine, Sertraline, and Venlafaxine in a Crossover Study: Intraindividual Variability and Plasma Concentration Correlations.
Published in:
Journal of Clinical Pharmacology, 2000, v. 40, n. 1, p. 58, doi. 10.1177/009127000004000108
By:
- Alfaro, Cara L.;
- Francis Lam, Y W;
- Simpson, Joseph;
- Ereshefsky, Larry
Publication type:
Article
Effects of the glycine reuptake inhibitors bitopertin and RG7118 on glycine in cerebrospinal fluid: results of two proofs of mechanism studies in healthy volunteers.
Published in:
Psychopharmacology, 2016, v. 233, n. 13, p. 2429, doi. 10.1007/s00213-016-4317-7
By:
- Hofmann, Carsten;
- Pizzagalli, Flavia;
- Boetsch, Christophe;
- Alberati, Daniela;
- Ereshefsky, Larry;
- Jhee, Stanford;
- Patat, Alain;
- Boutouyrie-Dumont, Bruno;
- Martin-Facklam, Meret
Publication type:
Article
Clinically Significant Psychotropic Drug-Drug Interactions in the Primary Care Setting.
Published in:
Current Psychiatry Reports, 2012, v. 14, n. 4, p. 376, doi. 10.1007/s11920-012-0284-9
By:
- English, Brett;
- Dortch, Marcus;
- Ereshefsky, Larry;
- Jhee, Stanford
Publication type:
Article
An evaluation of population pharmacokinetics in therapeutic trials. Part II. Detection of a drug-drug interaction.
Published in:
Clinical Pharmacology & Therapeutics, 1987, v. 42, n. 4, p. 433, doi. 10.1038/clpt.1987.174
By:
- Grasela, Thaddeus H;
- Antal, Edward J;
- Ereshefsky, Larry;
- Wells, Barbara G;
- Evans, R Lee;
- Smith, Randall B
Publication type:
Article
Effect of food on the pharmacokinetics of lurasidone: results of two randomized, open-label, crossover studies.
Published in:
Human Psychopharmacology: Clinical & Experimental, 2013, v. 28, n. 5, p. 495, doi. 10.1002/hup.2338
By:
- Preskorn, Sheldon;
- Ereshefsky, Larry;
- Chiu, Yu ‐ Yuan;
- Poola, Nagaraju;
- Loebel, Antony
Publication type:
Article
Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial.
Published in:
Journal of Psychopharmacology, 2012, v. 26, n. 12, p. 1525, doi. 10.1177/0269881112458728
By:
- Nations, Kari R;
- Dogterom, Peter;
- Bursi, Roberta;
- Schipper, Jacques;
- Greenwald, Scott;
- Zraket, David;
- Gertsik, Lev;
- Johnstone, Jack;
- Lee, Allen;
- Pande, Yogesh;
- Ruigt, Ge;
- Ereshefsky, Larry
Publication type:
Article
Schizophrenia: how should we look at it?
Published in:
1997
By:
- Miller, Alexander L.;
- Ereshefsky, Larry;
- Miller, A L;
- Ereshefsky, L
Publication type:
journal article
The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central Aβ Pharmacodynamic Responses in Mice, Dogs, and Humans.
Published in:
Journal of Neuroscience, 2015, v. 35, n. 3, p. 1199, doi. 10.1523/JNEUROSCI.4129-14.2015
By:
- May, Patrick C.;
- Willis, Brian A.;
- Lowe, Stephen L.;
- Dean, Robert A.;
- Monk, Scott A.;
- Cocke, Patrick J.;
- Audia, James E.;
- Boggs, Leonard N.;
- Borders, Anthony R.;
- Brier, Richard A.;
- Calligaro, David O.;
- Day, Theresa A.;
- Ereshefsky, Larry;
- Erickson, Jon A.;
- Gevorkyan, Hykop;
- Gonzales, Celedón R.;
- James, Douglas E.;
- Jhee, Stanford S.;
- Komjathy, Steven F.;
- Li, Linglin
Publication type:
Article
Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor.
Published in:
Journal of Neuroscience, 2011, v. 31, n. 46, p. 16507, doi. 10.1523/JNEUROSCI.3647-11.2011
By:
- May, Patrick C.;
- Dean, Robert A.;
- Lowe, Stephen L.;
- Martenyi, Ferenc;
- Sheehan, Scott M.;
- Boggs, Leonard N.;
- Monk, Scott A.;
- Mathes, Brian M.;
- Mergott, Dustin J.;
- Watson, Brian M.;
- Stout, Stephanie L.;
- Timm, David E.;
- LaBell, Elizabeth Smith;
- Gonzales, Celedon R.;
- Nakano, Masako;
- Jhee, Stanford S.;
- Yen, Mark;
- Ereshefsky, Larry;
- Lindstrom, Terry D.;
- Calligaro, David O.
Publication type:
Article

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