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- Title
Recent advances in pediatric rheumatology: October to December 2020.
- Authors
Anjani, Gummadi; Chaudhary, Himanshi; Singh, Surjit
- Abstract
AlAhmed et al. have analyzed 1285 patients with pSLE within the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry, of which 388 pSLE patients had comorbidities including autoimmune and non-autoimmune manifestations. It was found that simultaneous analysis of 4 different domains (namely, hematological parameters - lymphocyte percentage, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio; inflammatory parameters - C-reactive protein, erythrocyte sedimentation rate, procalcitonin; complement levels - C3, C4; and clinical disease activity and damage scores - Systemic Lupus Erythematosus Disease Activity Index, Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index) is helpful in differentiating infections from SLE flares in pSLE patients. Histopathological examination of 10 patients with positive serology revealed that 6 patients had changes consistent with CD, while 4 had normal histopathology. Patients with CTD and ILD had significantly higher levels of KL-6 as compared to patients with CTD without ILD and healthy controls.
- Subjects
MUCOCUTANEOUS lymph node syndrome; PEDIATRIC rheumatology; GENITAL warts; ACUTE phase proteins
- Publication
International Journal of Rheumatic Diseases, 2021, Vol 24, Issue 4, p608
- ISSN
1756-1841
- Publication type
Article
- DOI
10.1111/1756-185X.14090