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- Title
KiSl-A novel monoclonal antibody which recognizes proliferating cells: Evaluation of its relationship to prognosis in mammary carcinoma.
- Authors
Sampson, Steven A.; Kreipe, Hans; Gillett, Cheryl E.; Smith, Paul; Chaudary, Murid A.; Khan, Ashraf; Wicks, Kimberly; Parwaresch, R.; Barnes, Diana M.
- Abstract
Immunohistochemical staining with a novel monoclonal antibody, KiSl, which recognizes a cell cycle-associated antigen, was investigated in 142 cases of stage I and II invasive breast carcinoma. KiS 1 staining indices were compared with disease-free interval, overall survival, and post-relapse survival. Using a semi-quantitative method of assessment, we found that tumours with a high level of staining (34/142,24 per cent) had a significantly worse prognosis than those with a low level of staining (108/142, 76 per cent). Significant correlations were found between KiS1 staining and disease-free interval ( P<0·001), overall survival ( P<0·001), and post-relapse survival (P=0·008). A more time-consuming, quantitative method of assessment gave similar results. Cox multivariate analysis showed these results to be independent of nodal status, histological type, and grade of tumour ( P=0·01). We conclude that KiS1 is a valuable new antibody which affords useful prognostic information in breast carcinoma. As it can be used in formalin-fixed, paraffinembedded material, it may be of particular use in the study of small lesions such as those identified in the Breast Cancer Screening Programme.
- Publication
Journal of Pathology, 1992, Vol 168, Issue 2, p179
- ISSN
0022-3417
- Publication type
Article
- DOI
10.1002/path.1711680205