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- Title
Complement activation in the tubulointerstitium: AKI, CKD, and in between.
- Authors
Brar, Jyoti E; Quigg, Richard J
- Abstract
Complement activation is actively regulated to prevent injudicious activation, such as on peritubular endothelia and basolateral aspects of tubules. Miao et al. studied mice in which the key complement regulator, Crry, was deleted from tubular cells. This lacked functional consequence in unmanipulated animals. Yet, following ischemia-reperfusion, there was greater injury due to alternative pathway activation of C5. When the balance between complement activation and regulation is tipped towards the former, pathologic complement activation can ensue.
- Subjects
ENDOTHELIAL cells; KIDNEY tubules; ENZYME activation; COMPLEMENT activation; REPERFUSION
- Publication
Kidney International, 2014, Vol 86, Issue 4, p663
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2014.168