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Editorial: Recent advancements in mycobacterial diseases research.
Published in:
Frontiers in Microbiology, 2024, p. 1, doi. 10.3389/fmicb.2024.1504449
By:
- Johansen, Matt D.;
- Pasipanodya, Jotam G.;
- Subbian, Selvakumar;
- Venketaraman, Vishwanath
Publication type:
Article
Bacterial load slopes represent biomarkers of tuberculosis therapy success, failure, and relapse.
Published in:
Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02184-0
By:
- Magombedze, Gesham;
- Pasipanodya, Jotam G.;
- Gumbo, Tawanda
Publication type:
Article
Serum Drug Concentrations Predictive of Pulmonary Tuberculosis Outcomes.
Published in:
Journal of Infectious Diseases, 2013, v. 208, n. 9, p. 1464, doi. 10.1093/infdis/jit352
By:
- Pasipanodya, Jotam G.;
- McIlleron, Helen;
- Burger, André;
- Wash, Peter A.;
- Smith, Peter;
- Gumbo, Tawanda
Publication type:
Article
Reply to Alffenaar.
Published in:
2012
By:
- Srivastava, Shashikant;
- Pasipanodya, Jotam G.;
- Gumbo, Tawanda
Publication type:
Letter
Multidrug-Resistant Tuberculosis Not Due to Noncompliance but to Between-Patient Pharmacokinetic Variability.
Published in:
Journal of Infectious Diseases, 2011, v. 204, n. 12, p. 1951, doi. 10.1093/infdis/jir658
By:
- Srivastava, Shashikant;
- Pasipanodya, Jotam G.;
- Meek, Claudia;
- Leff, Richard;
- Gumbo, Tawanda
Publication type:
Article
Spatial Network Mapping of Pulmonary Multidrug-Resistant Tuberculosis Cavities Using RNA Sequencing.
Published in:
2019
By:
- Dheda, Keertan;
- Lenders, Laura;
- Srivastava, Shashikant;
- Magombedze, Gesham;
- Wainwright, Helen;
- Raj, Prithvi;
- Bush, Stephen J.;
- Pollara, Gabriele;
- Steyn, Rachelle;
- Davids, Malika;
- Pooran, Anil;
- Pennel, Timothy;
- Linegar, Anthony;
- McNerney, Ruth;
- Moodley, Loven;
- Pasipanodya, Jotam G.;
- Turner, Carolin T.;
- Noursadeghi, Mahdad;
- Warren, Robin M.;
- Wakeland, Edward
Publication type:
journal article
Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis.
Published in:
2018
By:
- Dheda, Keertan;
- Lenders, Laura;
- Magombedze, Gesham;
- Srivastava, Shashikant;
- Raj, Prithvi;
- Arning, Erland;
- Ashcraft, Paula;
- Bottiglieri, Teodoro;
- Wainwright, Helen;
- Pennel, Timothy;
- Linegar, Anthony;
- Moodley, Loven;
- Pooran, Anil;
- Pasipanodya, Jotam G;
- Sirgel, Frederick A;
- van Helden, Paul D;
- Wakeland, Edward;
- Warren, Robin M;
- Gumbo, Tawanda
Publication type:
journal article
Machine learning reveals that Mycobacterium tuberculosis genotypes and anatomic disease site impacts drug resistance and disease transmission among patients with proven extra-pulmonary tuberculosis.
Published in:
2020
By:
- Sibandze, Doctor B.;
- Magazi, Beki T.;
- Malinga, Lesibana A.;
- Maningi, Nontuthuko E.;
- Shey, Bong-Akee;
- Pasipanodya, Jotam G.;
- Mbelle, Nontombi N.
Publication type:
journal article
Relationship Between Drug Concentration in Tuberculosis Lesions, Epithelial Lining Fluid, and Clinical Outcomes.
Published in:
Clinical Infectious Diseases, 2021, v. 73, n. 9, p. e3374, doi. 10.1093/cid/ciaa1271
By:
- Pasipanodya, Jotam G;
- Gumbo, Tawanda
Publication type:
Article
Ethionamide Pharmacokinetics/Pharmacodynamics-derived Dose, the Role of MICs in Clinical Outcome, and the Resistance Arrow of Time in Multidrug-resistant Tuberculosis.
Published in:
Clinical Infectious Diseases, 2018, v. 67, p. S317, doi. 10.1093/cid/ciy609
By:
- Deshpande, Devyani;
- Pasipanodya, Jotam G;
- Mpagama, Stellah G;
- Srivastava, Shashikant;
- Bendet, Paula;
- Koeuth, Thearith;
- Lee, Pooi S;
- Heysell, Scott K;
- Gumbo, Tawanda
Publication type:
Article
Transformation Morphisms and Time-to-Extinction Analysis That Map Therapy Duration From Preclinical Models to Patients With Tuberculosis: Translating From Apples to Oranges.
Published in:
Clinical Infectious Diseases, 2018, v. 67, p. S349, doi. 10.1093/cid/ciy623
By:
- Magombedze, Gesham;
- Pasipanodya, Jotam G;
- Srivastava, Shashikant;
- Deshpande, Devyani;
- Visser, Marianne E;
- Chigutsa, Emmanuel;
- McIlleron, Helen;
- Gumbo, Tawanda
Publication type:
Article
Artificial intelligence–derived 3-Way Concentration-dependent Antagonism of Gatifloxacin, Pyrazinamide, and Rifampicin During Treatment of Pulmonary Tuberculosis.
Published in:
Clinical Infectious Diseases, 2018, v. 67, p. S284, doi. 10.1093/cid/ciy610
By:
- Pasipanodya, Jotam G;
- Smythe, Wynand;
- Merle, Corinne S;
- Olliaro, Piero L;
- Deshpande, Devyani;
- Magombedze, Gesham;
- McIlleron, Helen;
- Gumbo, Tawanda
Publication type:
Article
Levofloxacin Pharmacokinetics/Pharmacodynamics, Dosing, Susceptibility Breakpoints, and Artificial Intelligence in the Treatment of Multidrug-resistant Tuberculosis.
Published in:
Clinical Infectious Diseases, 2018, v. 67, p. S293, doi. 10.1093/cid/ciy611
By:
- Deshpande, Devyani;
- Pasipanodya, Jotam G;
- Mpagama, Stellah G;
- Bendet, Paula;
- Srivastava, Shashikant;
- Koeuth, Thearith;
- Lee, Pooi S;
- Bhavnani, Sujata M;
- Ambrose, Paul G;
- Thwaites, Guy
Publication type:
Article
Gatifloxacin Pharmacokinetics/Pharmacodynamics–based Optimal Dosing for Pulmonary and Meningeal Multidrug-resistant Tuberculosis.
Published in:
Clinical Infectious Diseases, 2018, v. 67, p. S274, doi. 10.1093/cid/ciy618
By:
- Deshpande, Devyani;
- Pasipanodya, Jotam G;
- Srivastava, Shashikant;
- Bendet, Paula;
- Koeuth, Thearith;
- Bhavnani, Sujata M;
- Ambrose, Paul G;
- Smythe, Wynand;
- McIlleron, Helen;
- Thwaites, Guy
Publication type:
Article
Intermediate Susceptibility Dose-Dependent Breakpoints For High-Dose Rifampin, Isoniazid, and Pyrazinamide Treatment in Multidrug-Resistant Tuberculosis Programs.
Published in:
Clinical Infectious Diseases, 2018, v. 67, n. 11, p. 1743, doi. 10.1093/cid/ciy346
By:
- Zuur, Marlanka A;
- Pasipanodya, Jotam G;
- Soolingen, Dick van;
- Werf, Tjip S van der;
- Gumbo, Tawanda;
- Alffenaar, Jan-Willem C
Publication type:
Article
Individualizing Tuberculosis (TB) Treatment: Are TB Programs in High Burden Settings Ready for Prime Time Therapeutic Drug Monitoring?
Published in:
2018
By:
- Pasipanodya, Jotam G;
- Gumbo, Tawanda
Publication type:
Letter to the Editor
Concentration-Dependent Antagonism and Culture Conversion in Pulmonary Tuberculosis.
Published in:
Clinical Infectious Diseases, 2017, v. 64, n. 10, p. 1350, doi. 10.1093/cid/cix158
By:
- Rockwood, Neesha;
- Pasipanodya, Jotam G.;
- Denti, Paolo;
- Sirgel, Frederick;
- Lesosky, Maia;
- Gumbo, Tawanda;
- Meintjes, Graeme;
- McIlleron, Helen;
- Wilkinson, Robert J.
Publication type:
Article
Linezolid for Infants and Toddlers With Disseminated Tuberculosis: First Steps.
Published in:
Clinical Infectious Diseases, 2016, v. 63, p. S80, doi. 10.1093/cid/ciw482
By:
- Deshpande, Devyani;
- Srivastava, Shashikant;
- Pasipanodya, Jotam G.;
- Bush, Stephen J.;
- Nuermberger, Eric;
- Swaminathan, Soumya;
- Gumbo, Tawanda
Publication type:
Article
A Faropenem, Linezolid, and Moxifloxacin Regimen for Both Drug-Susceptible and Multidrug-Resistant Tuberculosis in Children: FLAME Path on the Milky Way.
Published in:
Clinical Infectious Diseases, 2016, v. 63, p. S95, doi. 10.1093/cid/ciw474
By:
- Deshpande, Devyani;
- Srivastava, Shashikant;
- Nuermberger, Eric;
- Pasipanodya, Jotam G.;
- Swaminathan, Soumya;
- Gumbo, Tawanda
Publication type:
Article
Concentration-Dependent Synergy and Antagonism of Linezolid and Moxifloxacin in the Treatment of Childhood Tuberculosis: The Dynamic Duo.
Published in:
Clinical Infectious Diseases, 2016, v. 63, p. S88, doi. 10.1093/cid/ciw473
By:
- Deshpande, Devyani;
- Srivastava, Shashikant;
- Nuermberger, Eric;
- Pasipanodya, Jotam G.;
- Swaminathan, Soumya;
- Gumbo, Tawanda
Publication type:
Article
A Combination Regimen Design Program Based on Pharmacodynamic Target Setting for Childhood Tuberculosis: Design Rules for the Playground.
Published in:
Clinical Infectious Diseases, 2016, v. 63, p. S75, doi. 10.1093/cid/ciw472
By:
- Srivastava, Shashikant;
- Deshpande, Devyani;
- Pasipanodya, Jotam G.;
- Thomas, Tania;
- Swaminathan, Soumya;
- Nuermberger, Eric;
- Gumbo, Tawanda
Publication type:
Article
Drug Concentration Thresholds Predictive of Therapy Failure and Death in Children With Tuberculosis: Bread Crumb Trails in Random Forests.
Published in:
Clinical Infectious Diseases, 2016, v. 63, p. S63, doi. 10.1093/cid/ciw471
By:
- Swaminathan, Soumya;
- Pasipanodya, Jotam G.;
- Ramachandran, Geetha;
- Kumar, A. K. Hemanth;
- Srivastava, Shashikant;
- Deshpande, Devyani;
- Nuermberger, Eric;
- Gumbo, Tawanda
Publication type:
Article
Correlations Between the Hollow Fiber Model of Tuberculosis and Therapeutic Events in Tuberculosis Patients: Learn and Confirm.
Published in:
Clinical Infectious Diseases, 2015, v. 61, p. S18, doi. 10.1093/cid/civ426
By:
- Gumbo, Tawanda;
- Pasipanodya, Jotam G.;
- Nuermberger, Eric;
- Romero, Klaus;
- Hanna, Debra
Publication type:
Article
Systematic Analysis of Hollow Fiber Model of Tuberculosis Experiments.
Published in:
Clinical Infectious Diseases, 2015, v. 61, p. S10, doi. 10.1093/cid/civ425
By:
- Pasipanodya, Jotam G.;
- Nuermberger, Eric;
- Romero, Klaus;
- Gumbo, Tawanda
Publication type:
Article
Forecasting Accuracy of the Hollow Fiber Model of Tuberculosis for Clinical Therapeutic Outcomes.
Published in:
Clinical Infectious Diseases, 2015, v. 61, p. S25, doi. 10.1093/cid/civ427
By:
- Gumbo, Tawanda;
- Pasipanodya, Jotam G.;
- Romero, Klaus;
- Hanna, Debra;
- Nuermberger, Eric
Publication type:
Article
Reply to Moonan and Weis, Seaworth et al, and Nunn and Phillips.
Published in:
2013
By:
- Pasipanodya, Jotam G.;
- Gumbo, Tawanda
Publication type:
Letter
A Meta-Analysis of Self-Administered vs Directly Observed Therapy Effect on Microbiologic Failure, Relapse, and Acquired Drug Resistance in Tuberculosis Patients.
Published in:
Clinical Infectious Diseases, 2013, v. 57, n. 1, p. 21, doi. 10.1093/cid/cit167
By:
- Pasipanodya, Jotam G.;
- Gumbo, Tawanda
Publication type:
Article
Drug Concentration Monitoring in Mycobacterium avium Lung Disease: Problems with Methods and Conclusions.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2013, v. 187, n. 5, p. 554, doi. 10.1164/ajrccm.187.5.554
By:
- PASIPANODYA, JOTAM G.;
- GUMBO, TAWANDA;
- WON-JUNG Koh;
- BYEONG-HO JEONG;
- KYEONGMAN JEON;
- SOO-YOUN LEE;
- SUNG JAE SHIN
Publication type:
Article
Measuring health-related quality of life in tuberculosis: a systemic review - Response.
Published in:
2010
By:
- Weis, Stephen E.;
- Pasipanodya, Jotam G.
Publication type:
Letter
Comparative Effectiveness of Methotrexate versus Methylprednisolone in Treatment Naïve Pulmonary Sarcoidosis Patients.
Published in:
Diagnostics (2075-4418), 2021, v. 11, n. 8, p. 1401, doi. 10.3390/diagnostics11081401
By:
- Pasipanodya, Jotam G.
Publication type:
Article
Pulmonary impairment after tuberculosis and its contribution to TB burden.
Published in:
2010
By:
- Pasipanodya, Jotam G.;
- McNabb, Scott J. N.;
- Hilsenrath, Peter;
- Bae, Sejong;
- Lykens, Kristine;
- Vecino, Edgar;
- Munguia, Guadalupe;
- Miller, Thaddeus L.;
- Drewyer, Gerry;
- Weis, Stephen E.;
- McNabb, Scott Jn
Publication type:
journal article
Minocycline Immunomodulates via Sonic Hedgehog Signaling and Apoptosis and Has Direct Potency Against Drug-Resistant Tuberculosis.
Published in:
2019
By:
- Deshpande, Devyani;
- Pasipanodya, Jotam G;
- Srivastava, Shashikant;
- Martin, Katherine R;
- Athale, Shruti;
- Zyl, Johanna van;
- Antiabong, John;
- Koeuth, Thearith;
- Lee, Pooi S;
- Dheda, Keertan;
- Gumbo, Tawanda;
- van Zyl, Johanna
Publication type:
journal article
Urine colorimetry to detect Low rifampin exposure during tuberculosis therapy: a proof-of-concept study.
Published in:
2016
By:
- Zentner, Isaac;
- Schlecht, Hans P.;
- Khensouvann, Lorna;
- Tamuhla, Neo;
- Kutzler, Michele;
- Ivaturi, Vijay;
- Pasipanodya, Jotam G.;
- Gumbo, Tawanda;
- Peloquin, Charles A.;
- Bisson, Gregory P.;
- Vinnard, Christopher
Publication type:
journal article
Therapy duration and long-term outcomes in extra-pulmonary tuberculosis.
Published in:
BMC Infectious Diseases, 2014, v. 14, n. 1, p. 1, doi. 10.1186/1471-2334-14-115
By:
- Pusch, Tobias;
- Pasipanodya, Jotam G.;
- Hall II, Ronald G.;
- Gumbo, Tawanda
Publication type:
Article
Therapy duration and long-term outcomes in extra-pulmonary tuberculosis.
Published in:
2014
By:
- Pusch, Tobias;
- Pasipanodya, Jotam G;
- Hall 2nd, Ronald G;
- Gumbo, Tawanda;
- Hall, Ronald G 2nd
Publication type:
journal article
Hollow-fibre system model of tuberculosis reproducibility and performance specifications for best practice in drug and combination therapy development.
Published in:
Journal of Antimicrobial Chemotherapy (JAC), 2023, v. 78, n. 4, p. 953, doi. 10.1093/jac/dkad029
By:
- Gumbo, Tawanda;
- Srivastava, Shashikant;
- Deshpande, Devyani;
- Pasipanodya, Jotam G;
- Berg, Alexander;
- Romero, Klaus;
- Hermann, David;
- Hanna, Debra
Publication type:
Article
Omadacycline efficacy in the hollow fibre system model of pulmonary Mycobacterium avium complex and potency at clinically attainable doses.
Published in:
2022
By:
- Chapagain, Moti;
- Pasipanodya, Jotam G.;
- Athale, Shruti;
- Bernal, Claude;
- Trammell, Rachel;
- Howe, David;
- Gumbo, Tawanda
Publication type:
journal article
Optimizing ethambutol dosing among HIV/tuberculosis co-infected patients: a population pharmacokinetic modelling and simulation study.
Published in:
2019
By:
- Mehta, Krina;
- Ravimohan, Shruthi;
- Pasipanodya, Jotam G;
- Srivastava, Shashikant;
- Modongo, Chawangwa;
- Zetola, Nicola M;
- Weissman, Drew;
- Ivaturi, Vijay;
- Gumbo, Tawanda;
- Bisson, Gregory P;
- Vinnard, Christopher
Publication type:
journal article
The discovery of ceftazidime/avibactam as an anti-Mycobacterium avium agent.
Published in:
2017
By:
- Deshpande, Devyani;
- Srivastava, Shashikant;
- Chapagain, Moti. L.;
- Lee, Pooi S.;
- Cirrincione, Kayle N.;
- Pasipanodya, Jotam G.;
- Gumbo, Tawanda
Publication type:
journal article
Tedizolid is highly bactericidal in the treatment of pulmonary Mycobacterium avium complex disease.
Published in:
2017
By:
- Deshpande, Devyani;
- Srivastava, Shashikant;
- Pasipanodya, Jotam G.;
- Lee, Pooi S.;
- Gumbo, Tawanda
Publication type:
journal article
A novel ceftazidime/avibactam, rifabutin, tedizolid and moxifloxacin (CARTM) regimen for pulmonary Mycobacterium avium disease.
Published in:
2017
By:
- Deshpande, Devyani;
- Srivastava, Shashikant;
- Pasipanodya, Jotam G.;
- Lee, Pooi S.;
- Gumbo, Tawanda
Publication type:
journal article
Linezolid as treatment for pulmonary Mycobacterium avium disease.
Published in:
2017
By:
- Deshpande, Devyani;
- Srivastava, Shashikant;
- Pasipanodya, Jotam G.;
- Gumbo, Tawanda
Publication type:
journal article
Meta-analyses and the evidence base for microbial outcomes in the treatment of pulmonary Mycobacterium avium-intracellulare complex disease.
Published in:
2017
By:
- Pasipanodya, Jotam G.;
- Ogbonna, Deborah;
- Deshpande, Devyani;
- Srivastava, Shashikant;
- Gumbo, Tawanda
Publication type:
journal article
Comment on: Clinical significance of 2 h plasma concentrations of first-line anti-tuberculosis drugs: a prospective observational study.
Published in:
2015
By:
- Pasipanodya, Jotam G;
- Srivastava, Shashikant;
- Gumbo, Tawanda
Publication type:
Journal Article
Meta-Analysis of Clinical Studies Supports the Pharmacokinetic Variability Hypothesis for Acquired Drug Resistance and Failure of Antituberculosis Therapy.
Published in:
Clinical Infectious Diseases, 2012, v. 55, n. 2, p. 169, doi. 10.1093/cid/cis353
By:
- Pasipanodya, Jotam G.;
- Srivastava, Shashikant;
- Gumbo, Tawanda
Publication type:
Article

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