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- Title
Neutrophil Activation and Immune Thrombosis Profiles Persist in Convalescent COVID-19.
- Authors
Hocini, Hakim; Wiedemann, Aurélie; Blengio, Fabiola; Lefebvre, Cécile; Cervantes-Gonzalez, Minerva; Foucat, Emile; Tisserand, Pascaline; Surenaud, Mathieu; Coléon, Séverin; Prague, Mélanie; Guillaumat, Lydia; Krief, Corinne; Fenwick, Craig; Laouénan, Cédric; Bouadma, Lila; Ghosn, Jade; Pantaleo, Giuseppe; Thiébaut, Rodolphe; Abel, Laurent; Abrous, Amal
- Abstract
Purpose: Following a severe COVID-19 infection, a proportion of individuals develop prolonged symptoms. We investigated the immunological dysfunction that underlies the persistence of symptoms months after the resolution of acute COVID-19. Methods: We analyzed cytokines, cell phenotypes, SARS-CoV-2 spike-specific and neutralizing antibodies, and whole blood gene expression profiles in convalescent severe COVID-19 patients 1, 3, and 6 months following hospital discharge. Results: We observed persistent abnormalities until month 6 marked by (i) high serum levels of monocyte/macrophage and endothelial activation markers, chemotaxis, and hematopoietic cytokines; (ii) a high frequency of central memory CD4+ and effector CD8+ T cells; (iii) a decrease in anti-SARS-CoV-2 spike and neutralizing antibodies; and (iv) an upregulation of genes related to platelet, neutrophil activation, erythrocytes, myeloid cell differentiation, and RUNX1 signaling. We identified a "core gene signature" associated with a history of thrombotic events, with upregulation of a set of genes involved in neutrophil activation, platelet, hematopoiesis, and blood coagulation. Conclusion: The lack of restoration of gene expression to a normal profile after up to 6 months of follow-up, even in asymptomatic patients who experienced severe COVID-19, signals the need to carefully extend their clinical follow-up and propose preventive measures.
- Subjects
POST-acute COVID-19 syndrome; NEUTROPHILS; MYELOID cells; GENE expression profiling; COVID-19; HYPERCOAGULATION disorders; PSYCHONEUROIMMUNOLOGY
- Publication
Journal of Clinical Immunology, 2023, Vol 43, Issue 5, p882
- ISSN
0271-9142
- Publication type
Article
- DOI
10.1007/s10875-023-01459-x