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- Title
Effect of Bisphosphonates on Anodized and Heat-Treated Titanium Surfaces: An Animal Experimental Study.
- Authors
Seung-Jae Lee; Tae-Ju Oh; Tae-Sung Bae; Min-Ho Lee; Yunjo Soh; Byung-Il Kim; Hyung Seop Kim
- Abstract
Background: Recent investigations reported that osseointegration of titanium implants can be significantly reinforced with a nanostructure treated with anodic oxidation and heat treatment. This experimental study investigates the effect of bisphosphonates on the nanotubular implant surface in rats. Methods: Thirty-six titanium implants were divided into three groups: 1) machine-turned (MT), 2) anodized and heat-treated (AH), and 3) anodized and heat- and bisphosphonatetreated (AHB) groups. The 36 implants were randomly placed in both tibias of 18 male Wistar rats. After 2 and 4 weeks, the levels of osseointegration of the implants were evaluated by a removal torque test and microcomputerized tomography (µCT). Peri-implant bone tissue on the extracted region was examined for the expression of type I collagen and osteocalcin. Results: The AHB group showed the highest removal torque at 2 and 4 weeks ( 13.92 ± 1.51 Ncm and 18.10 ± 2.15 Ncm, respectively) followed, in order, by the AH group (11.63 ± 1.58 Ncm at 2 weeks and 14.80 ± 2.34 Ncm at 4 weeks) and MT group (4.30 ± 0.76 Ncm at 2 weeks and 6.20 ± 1.33 Ncm at 4 weeks) with statistically significant differences between the MT and other two groups at both time points. µCT images also revealed a denser appearance around implants in the AHB group than in the other groups. Levels of type I collagen and osteocalcin expression were similar between the MT and AH groups; however, the values were significantly higher in the AHB group compared to the other groups, which were 220.85% 4- 71.09% and 363.04% ± 100.21%, respectively (P <0.05). Conclusion: Within the limits of this experiment, it was concluded that surface loading with bisphosphonates significantly improved the degree of osseointegration of titanium implants with a na nostructure.
- Subjects
DIPHOSPHONATES; TITANIUM; ANODIC oxidation of metals; NANOTUBES; DENTAL implants; OSSEOINTEGRATION; OSSEOINTEGRATED dental implants; LABORATORY rats
- Publication
Journal of Periodontology, 2011, Vol 82, Issue 7, p1035
- ISSN
0022-3492
- Publication type
Article
- DOI
10.1902/jop.2010.100608