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- Title
Focal Encephalitis Following Varicella-Zoster Virus Reactivation Without Rash in a Healthy Immunized Young Adult.
- Authors
Halling, Geoffrey; Giannini, Caterina; Britton, Jeffrey W.; Lee, Ricky W.; Watson, Robert E.; Terrell, Christine L.; Parney, Ian F.; Buckingham, Erin M.; Carpenter, John E.; Grose, Charles
- Abstract
Herein we describe an episode of focal varicella-zoster virus (VZV) encephalitis in a healthy young man with neither rash nor radicular pain. The symptoms began with headaches and seizures, after which magnetic resonance imaging detected a single hyperintense lesion in the left temporal lobe. Because of the provisional diagnosis of a brain tumor, the lesion was excised and submitted for pathological examination. No tumor was found. But the tissue immunostained positively for VZV antigens, and wild-type VZV sequences were detected. In short, this case represents VZV reactivation, most likely in the trigeminal ganglion, in the absence of clinical herpes zoster.
- Subjects
VARICELLA-zoster virus diseases; ENCEPHALITIS; DISEASES in young adults; MAGNETIC resonance imaging; SYMPTOMS; VACCINATION
- Publication
Journal of Infectious Diseases, 2014, Vol 210, Issue 5, p713
- ISSN
0022-1899
- Publication type
Case Study
- DOI
10.1093/infdis/jiu137