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- Title
Evidence for Influenza Virus CNS Invasion Along the Olfactory Route in an Immunocompromised Infant.
- Authors
van Riel, Debby; Leijten, Lonneke M.; Verdijk, Rob M.; GeurtsvanKessel, Corine; van der Vries, Erhard; van Rossum, Annemarie M.C.; Osterhaus, Ab D. M. E.; Kuiken, Thijs
- Abstract
Central nervous system (CNS) disease is the most common extrarespiratory complication of influenza in humans. However, the pathogenesis, including the route of virus entry, is largely unknown. Here we present, for the first time, evidence of influenza virus entry into the CNS via the olfactory route in an immune-compromised infant. Since the nasal cavity is a primary site of influenza virus replication and is directly connected to the CNS via the olfactory nerve, these results imply that influenza virus invasion of the CNS may occur more often than previously believed.
- Subjects
CENTRAL nervous system disease complications; INFLUENZA viruses; VIRUS diseases; IMMUNOCOMPROMISED patients; OLFACTORY nerve
- Publication
Journal of Infectious Diseases, 2014, Vol 210, Issue 3, p419
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiu097