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- Title
Let-7a elevates p21<sup>WAF1</sup> levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells
- Authors
He, Xiaoyan; Duan, Changzhu; Chen, Junxia; Ou-Yang, Xi; Zhang, Zheng; Li, Chunlei; Peng, Huimin
- Abstract
Abstract: Down-regulation of let-7 microRNA (miRNA) is a key event in lung cancer. Despite recent advances in survival signaling, the roles of let-7 in the context of lung cancer are not fully clear. In this study, we showed that let-7a, a member of let-7 family, negatively regulated the expression of NIRF through NIRF 3′ UTR. We also showed that NIRF was required for the let-7a-mediated elevation of p21WAF1. These findings suggest that growth-inhibitory effect of let-7a on the A549 cells in vitro and in vivo may be explained in part by le-7a-induced suppression of NIRF and elevation of p21WAF1. This work reveals a novel regulatory mechanism for let-7a in the control of cellular proliferation and lung carcinogenesis.
- Subjects
LUNG cancer; CELL proliferation; CARCINOGENESIS; CANCER cell growth regulation; CANCER research
- Publication
FEBS Letters, 2009, Vol 583, Issue 21, p3501
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2009.10.007