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- Title
Positive-feedback loops in cell cycle progression
- Authors
Pomerening, Joseph R.
- Abstract
Abstract: A positive-feedback loop is a simple motif that is ubiquitous to the modules and networks that comprise cellular signaling systems. Signaling behaviors that are synonymous with positive feedback include amplification and rapid switching, maintenance, and the coherence of outputs. Recent advances have been made towards understanding how positive-feedback loops function, as well as their mechanistic basis in controlling eukaryotic cell cycle progression. Some of these advances will be reviewed here, including: how cyclin controls passage through Start and maintains coherence of G1/S regulon expression in yeast; how Polo-like kinase 1 activation is driven by Bora and Aurora A, and its expression is stimulated by Forkhead Box M1 in mammalian cells; and how some of the various dynamic behaviors of spindle assembly and anaphase onset can be produced.
- Subjects
CELL cycle regulation; EUKARYOTIC cells; CELLULAR signal transduction; CYCLIN-dependent kinases; GENE amplification; GENE expression
- Publication
FEBS Letters, 2009, Vol 583, Issue 21, p3388
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2009.10.001