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- Title
TNF-α and adipocyte biology
- Authors
Cawthorn, William P.; Sethi, Jaswinder K.
- Abstract
Abstract: Dyslipidemia and insulin resistance are commonly associated with catabolic or lipodystrophic conditions (such as cancer and sepsis) and with pathological states of nutritional overload (such as obesity-related type 2 diabetes). Two common features of these metabolic disorders are adipose tissue dysfunction and elevated levels of tumour necrosis factor-alpha (TNF-α). Herein, we review the multiple actions of this pro-inflammatory adipokine on adipose tissue biology. These include inhibition of carbohydrate metabolism, lipogenesis, adipogenesis and thermogenesis and stimulation of lipolysis. TNF-α can also impact the endocrine functions of adipose tissue. Taken together, TNF-α contributes to metabolic dysregulation by impairing both adipose tissue function and its ability to store excess fuel. The molecular mechanisms that underlie these actions are discussed.
- Subjects
METABOLIC disorders; FAT cells; TUMORS; PATHOLOGY
- Publication
FEBS Letters, 2008, Vol 582, Issue 1, p117
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.11.051