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- Title
The hetero-oligomeric complex of the S100A8/S100A9 protein is extremely protease resistant
- Authors
Nacken, Wolfgang; Kerkhoff, Claus
- Abstract
Abstract: S100A8, S100A9 and S100A12 proteins are associated with inflammation and tissue remodelling, both processes known to be associated with high protease activity. Here, we report that homo-oligomeric forms of S100A8 and S100A9 are readily degraded by proteases, but that the preferred hetero-oligomeric S100A8/A9 complex displays a high resistance even against proteinase K degradation. S100A12 is not as protease resistant as the S100A8/A9 complex. Since specific functions have been assigned to the homo- and heterooligomeric forms of the S100A8 and A9 proteins, this finding may point to a post-translational level of regulation of the various functions of these proteins in inflammation and tissue remodelling.
- Subjects
PROTEINS; INFLAMMATION; PROTEOLYTIC enzymes; PROTEINASES
- Publication
FEBS Letters, 2007, Vol 581, Issue 26, p5127
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.09.060