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- Title
RFX-1, a putative alpha Adducin interacting protein in a human kidney library
- Authors
Boito, Rosalia; Menniti, Miranda; Amato, Rosario; Palmieri, Camillo; Marinaro, Cinzia; Iuliano, Rodolfo; Tripodi, Grazia; Cusi, Daniele; Fuiano, Giorgio; Perrotti, Nicola
- Abstract
Abstract: Adducin regulates tubular absorption of sodium by modulating the expression levels of the sodium–potassium-ATPase in renal tubular cells. Adducin is a candidate gene in the pathogenesis of hypertension. Yeast two hybrid screen showed a specific interaction between human alpha Adducin and the regulatory factor for X box (RFX-1), a nuclear protein that down regulates the expression of several proteins in non neuronal cells. The interaction was confirmed in cells through coimmunoprecipitation and colocalization experiments. The binding of alpha Adducin to RFX-I and their nuclear co-localization suggests that Adducin can have a role in modulating the transcriptional regulating activity of RFX-I.
- Subjects
YEAST; HYPERTENSION; ADENOSINE triphosphatase; BLOOD circulation disorders
- Publication
FEBS Letters, 2005, Vol 579, Issue 28, p6439
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.10.040