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- Title
Low and high body mass index in hidradenitis suppurativa patients—different subtypes?
- Authors
Theut Riis, P.; Saunte, D.M.; Benhadou, F.; del Marmol, V.; Guillem, P.; El‐Domyati, M.; Abdel‐Wahab, H.; Antoniou, C.; Dessinioti, C.; Gürer, M.A.; Beksaç, B.; Szepietowski, J.C.; Matusiak, L.; Emtestam, L.; Lapins, J.; Riad, H.; Doss, N.; Massa, A.F.; Hamzavi, I.; Nicholson, C.
- Abstract
Introduction Overweight is a well-established risk factor for hidradenitis suppurativa (HS). In this cross-sectional study, we compare HS patients with a high body mass index (BMI) with HS patients with a low BMI to investigate differences in disease characteristics. Materials and method Patients were recruited from 17 dermatological centres from four continents. A total of 246 patients with a BMI below 25 were compared to 205 patients with a BMI of above 35. Results Patients with a high BMI suffered more severe disease (Hurley, physician global assessment, number of areas affected and patient-reported severity (PRS), P < 0.001 for all). There was no difference in smoking (P = 0.783) nor in family history (P = 0.088). In both low and high BMI patients, early onset of HS was a predictor of positive family history (P < 0.001, for each). For low BMI patients, an increase in BMI significantly increased PRS (P < 0.001). For patients with a high BMI, number of pack-years significantly increased PRS (P = 0.001). Cluster analysis of eruption patterns was location specific for low BMI patients but severity specific for high BMI patients. Discussion Patients with a low and high BMI could represent two clinically different subtypes. We suggest a non-linear relationship between BMI and impact of HS. As patients go from a low BMI patient to a high BMI patient (or from high to low), eruption patterns and risk factors may change.
- Subjects
HIDRADENITIS suppurativa; BODY mass index; OVERWEIGHT persons; SKIN diseases; TISSUE wounds
- Publication
Journal of the European Academy of Dermatology & Venereology, 2018, Vol 32, Issue 2, p307
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/jdv.14599