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- Title
Nationwide comprehensive human papillomavirus (HPV) genotyping of invasive cervical cancer.
- Authors
Lagheden, Camilla; Eklund, Carina; Lamin, Helena; Kleppe, Sara Nordqvist; Lei, Jiayao; Elfström, K. Miriam; Sundström, Karin; Andrae, Bengt; Sparén, Pär; Dillner, Joakim
- Abstract
<bold>Background: </bold>The Swedish National Cervical Screening Registry collects and evaluates comprehensive, nationwide health data to optimise organised cervical cancer prevention. Since all cervical cancer specimens are saved in biobanks, population-based data from the specimens should be available for analysis and linkage with other health information.<bold>Methods: </bold>We identified all cervical cancers diagnosed in Sweden during 2002-2011 (4254 confirmed cases) and requested the tissue blocks to retrieve human papillomavirus (HPV) genotype data using general primer PCR with Luminex genotyping and real-time PCR targeting the E6/E7 regions of HPV16/18.<bold>Results: </bold>We obtained blocks from 2932/4254 (69%) of cases. Valid HPV genotyping data was retrieved for 2850 cases (97%). The most common type was HPV16 (60%), followed by HPV18 (19%), HPV45 (7%), HPV31 (3%), HPV33 (2%), HPV52 (2%), HPV39 (1%), HPV70 (1%), HPV56 (1%), HPV35 (1%), HPV58 (1%) and HPV59 (1%). Ninety-six percent of all HPV-positive cases had a single infection. Eighty-nine cases were HPV-positive only when testing for the HPV16/18-E6/E7 region.<bold>Conclusions: </bold>We present one of the largest series of HPV-genotyped cervical cancers to date. The systematic collection of cervical cancer HPV genotyping data by the screening registry will facilitate prevention and monitoring of HPV type-specific disease burden.
- Publication
British Journal of Cancer, 2018, Vol 118, Issue 10, p1377
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/s41416-018-0053-6