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- Title
Incidence and time trends of brain metastases admissions among breast cancer patients in Sweden.
- Authors
Frisk, G; Svensson, T; Bäcklund, L M; Lidbrink, E; Blomqvist, P; Smedby, K E
- Abstract
Background:While treatment for breast cancer has been refined and overall survival has improved, there is concern that the incidence of brain metastases has increased.Methods:We identified patients in Sweden with incident breast cancer 1998-2006 in the National Cancer Register, and matched these to the National Patient Register to obtain information on hospital admissions for distant metastases. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed with Cox regression as estimates of relative risk.Results:Among 50 528 breast cancer patients, 696 (1.4%) were admitted with brain metastases during median 3.5 years of follow-up. Admissions for other metastases were found in 3470 (6.9%) patients. Compared with the period 1998-2000, patients diagnosed with breast cancer 2004-2006 were at a 44% increased risk of being admitted with brain metastases (HR 1.44, 95% CI 1.13-1.85).Conclusion:The incidence of admissions with brain metastases in breast cancer patients was increasing in the mid-2000s in Sweden. These findings support a true increase in incidence of brain metastases among breast cancer patients.
- Subjects
SWEDEN; BRAIN metastasis; BREAST cancer; CANCER patients; CANCER treatment; COHORT analysis
- Publication
British Journal of Cancer, 2012, Vol 106, Issue 11, p1850
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1038/bjc.2012.163