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- Title
The Use of Noninvasive Scores in Predicting NAFLD Progression After Bariatric Surgery.
- Authors
Ahmed, Leaque; Gebran, Selim; Persaud, Amrita; Saeed, Kashif; Khan, Khuram; Saeed, Saqib; Alothman, Sara; Passos-Fox, Bianca; DePaz, Hector; Suman, Paritosh
- Abstract
Background: Bariatric surgery has been postulated to impact liver function resulting in favorable effects on nonalcoholic fatty liver disease (NAFLD). We aimed to analyze the long-term impact of bariatric surgery on noninvasive scores predicting the progression of liver fibrosis in a bariatric population. Methods: We retrospectively reviewed the records of patients without pre-existing liver disease who underwent sleeve gastrectomy or Roux-en-Y gastric bypass (RYGB) at our center between 2010 and 2018. Four predictive scores for liver fibrosis (AST/ALT, APRI, Fib-4, and BARD) were calculated preoperatively, 6 months post-operatively, and annually up to 5 years. Correlations were analyzed with Pearson R. Subgroup and sensitivity analyses were performed to identify populations at increased risk. Results: A total of 2769 patients were included. The mean age was 40 years, and the majority was females (88.5%) and of Hispanic ethnicity (59.2%). There was a steady post-operative increase in the percentage of patients at increased risk of progression of liver fibrosis. The Fib-4 score showed the largest increase in the population at risk for liver fibrosis (11.3% preoperatively to 28.9% at 5 years). Patients with diabetes and those who underwent a sleeve gastrectomy continued to display a higher risk for liver fibrosis than did patients without diabetes and those who underwent RYGB, respectively. Conclusion: There was an overall trend to increased liver fibrosis scores over the 5-year post-operative follow-up, but this increase remained lower than that reported in previous literature. Bariatric surgery offers NAFLD risk reduction in a high-risk population.
- Subjects
BARIATRIC surgery; HEPATIC fibrosis; GASTRIC bypass; LIVER histology; NON-alcoholic fatty liver disease; SLEEVE gastrectomy; LIVER diseases
- Publication
Obesity Surgery, 2023, Vol 33, Issue 12, p4026
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-023-06912-9