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- Title
Significance of aneuploid stemlines in testicular nonseminomatous germ cell tumors.
- Authors
de Graaff, Willem E.; Sleijfer, Dirk Th.; de Jong, Bauke; Dam, Anke; Koops, Heimen Schraffordt; Oosterhuis, J. Wolter; de Graaff, W E; Sleijfer, D T; de Jong, B; Dam, A; Schraffordt Koops, H; Oosterhuis, J W
- Abstract
<bold>Background: </bold>Hyperpentaploidy in testicular nonseminomatous germ cell tumors (TNSGCT) has been associated with progression of disease of patients who initially had TNSGCT in Stage I.<bold>Methods: </bold>The authors used flow cytometry to investigate the relationship between ploidy and the clinical behavior in TNSGCT, focusing on hypertetraploid values (DNA index, > 2.00).<bold>Results: </bold>Patients with TNSGCT containing an aneuploid stemline with a hypertetraploid value more often had higher clinical stage of disease and a higher chance of relapse in advanced stages. The presence of multiple aneuploid stemlines in the tumors was found more frequently in patients who had higher clinical stage disease.<bold>Conclusions: </bold>The results suggest that the presence of highly aneuploid or multiple aneuploid stemlines in TNSGCT are associated with a clinically more malignant behavior.
- Publication
Cancer (0008543X), 1993, Vol 72, Issue 4, p1300
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19930815)72:4<1300::AID-CNCR2820720424>3.0.CO;2-O